Grimes, H. Leighton

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

Northcott, P. A., Lee, C., Zichner, T., Stütz, A. M., Erkek, S., Kawauchi, D., Shih, D. J. H., Hovestadt, V., Zapatka, M., Sturm, D., et al. (2014) · Nature

Glioma Diagnosis and TreatmentChromatin Remodeling and Cancer

Cited by 642

Single-cell analysis of mixed-lineage states leading to a binary cell fate choice

Olsson, A., Venkatasubramanian, M., Chaudhri, V. K., Aronow, B. J., Salomonis, N., Singh, H., & Grimes, H. L. (2016) · Nature

Single-cell and spatial transcriptomicsGene Regulatory Network Analysis

Cited by 476

Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes

Yáñez, A., Coetzee, S. G., Olsson, A., Muench, D. E., Berman, B. P., Hazelett, D. J., Salomonis, N., Grimes, H. L., & Goodridge, H. S. (2017) · Immunity

Immune cells in cancerImmunotherapy and Immune Responses

Cited by 470

The Human Cell Atlas bone marrow single-cell interactive web portal

Hay, S. B., Ferchen, K., Chetal, K., Grimes, H. L., & Salomonis, N. (2018) · Experimental Hematology

Single-cell and spatial transcriptomicsHematopoietic Stem Cell Transplantation

Cited by 256

DoubletDecon: Deconvoluting Doublets from Single-Cell RNA-Sequencing Data

DePasquale, E. A. K., Schnell, D. J., Van Camp, P.-J., Valiente-Alandí, Í., Blaxall, B. C., Grimes, H. L., Singh, H., & Salomonis, N. (2019) · Cell Reports

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

Cited by 207

Mouse models of neutropenia reveal progenitor-stage-specific defects

Muench, D. E., Olsson, A., Ferchen, K., Pham, G., Serafin, R. A., Chutipongtanate, S., Dwivedi, P., Song, B., Hay, S., Chetal, K., et al. (2020) · Nature

Blood disorders and treatmentsImmunodeficiency and Autoimmune Disorders

Cited by 115

Epigenetic Regulation of Protein-Coding and MicroRNA Genes by the Gfi1-Interacting Tumor Suppressor PRDM5

Duan, Z., Person, R. E., Lee, H.-H., Huang, S., Donadieu, J., Badolato, R., Grimes, H. L., Papayannopoulou, T., & Horwitz, M. S. (2007) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsBlood disorders and treatments

Cited by 91

A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes

Fang, J., Liu, X., Bolanos, L., Barker, B., Rigolino, C., Cortelezzi, A., Oliva, E. N., Cuzzola, M., Grimes, H. L., Fontanillo, C., et al. (2016) · Nature Medicine

Acute Myeloid Leukemia ResearchProtein Degradation and Inhibitors

Cited by 83

HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms

Yue, L., Sharma, V., Horvat, N. P., Akuffo, A. A., Beatty, M. S., Murdun, C., Colin, C., Billington, J. M. R., Goodheart, W. E., Sahakian, E., et al. (2020) · Blood

Myeloproliferative Neoplasms: Diagnosis and TreatmentHistone Deacetylase Inhibitors Research

Cited by 67

cellHarmony: cell-level matching and holistic comparison of single-cell transcriptomes

DePasquale, E. A. K., Schnell, D., Dexheimer, P., Ferchen, K., Hay, S., Chetal, K., Valiente-Alandí, Í., Blaxall, B. C., Grimes, H. L., & Salomonis, N. (2019) · Nucleic Acids Research

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 67