Helmlinger, Gabriel

Solid stress inhibits the growth of multicellular tumor spheroids

Helmlinger, G., Netti, P. A., Lichtenbeld, H. C., Melder, R. J., & Jain, R. K. (1997) · Nature Biotechnology

Cellular Mechanics and InteractionsMathematical Biology Tumor Growth

Cited by 859

Why do SGLT2 inhibitors reduce heart failure hospitalization? Adifferential volume regulation hypothesis

Hallow, K. M., Helmlinger, G., Greasley, P. J., McMurray, J. J. V., & Boulton, D. W. (2018) · Diabetes, Obesity and Metabolism

Heart Failure Treatment and ManagementDiabetes Treatment and Management

Cited by 499

A Mechanistic Tumor Penetration Model to Guide Antibody Drug Conjugate Design

Vasalou, C., Helmlinger, G., & Gomes, B. (2015) · PLOS ONE

Mathematical Biology Tumor GrowthNanoparticle-Based Drug Delivery

Cited by 98

Primary proximal tubule hyperreabsorption and impaired tubular transport counterregulation determine glomerular hyperfiltration in diabetes: a modeling analysis

Hallow, K. M., Gebremichael, Y., Helmlinger, G., & Vallon, V. (2017) · American Journal of Physiology-Renal Physiology

Chronic Kidney Disease and DiabetesIon Transport and Channel Regulation

Cited by 98

Evaluation of renal and cardiovascular protection mechanisms of SGLT2 inhibitors: model-based analysis of clinical data

Hallow, K. M., Greasley, P. J., Helmlinger, G., Chu, L., Heerspink, H. J., & Boulton, D. W. (2018) · American Journal of Physiology-Renal Physiology

Diabetes Treatment and ManagementChronic Kidney Disease and Diabetes

Cited by 68

Drug-disease modeling in the pharmaceutical industry-where mechanistic systems pharmacology and statistical pharmacometrics meet

Helmlinger, G., Al-Huniti, N., Aksenov, S., Peskov, K., Hallow, K. M., Chu, L., Boulton, D., Eriksson, U., Hamrén, B., Lambert, C., et al. (2017) · European Journal of Pharmaceutical Sciences

Statistical Methods in Clinical TrialsPharmaceutical studies and practices

Cited by 33