Påhlman, Sven

Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype

Holmquist-Mengelbier, L., Fredlund, E., Löfstedt, T., Noguera, R., Navarro, S., Nilsson, H., Pietras, A., Vallon-Christersson, J., Borg, Å., Gradin, K., et al. (2006) · Cancer Cell

Cancer, Hypoxia, and MetabolismNeuroblastoma Research and Treatments

Cited by 735

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

Wigerup, C., Påhlman, S., & Bexell, D. (2016) · Pharmacology & Therapeutics

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 687

Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype

Jögi, A., Øra, I., Nilsson, H., Lindeheim, Å., Makino, Y., Poellinger, L., Axelson, H., & Påhlman, S. (2002) · Proceedings of the National Academy of Sciences

Neuroblastoma Research and TreatmentsCancer, Hypoxia, and Metabolism

Cited by 399

HIF-2α maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells

Pietras, A., Hansford, L. M., Johnsson, A. S., Bridges, E., Sjölund, J., Gisselsson, D., Rehn, M., Beckman, S., Noguera, R., Navarro, S., et al. (2009) · Proceedings of the National Academy of Sciences

Neuroblastoma Research and TreatmentsCancer, Hypoxia, and Metabolism

Cited by 135

High levels of HIF‐2α highlight an immature neural crest‐like neuroblastoma cell cohort located in a perivascular niche

Pietras, A., Gisselsson, D., Øra, I., Noguera, R., Beckman, S., Navarro, S., & Påhlman, S. (2008) · The Journal of Pathology

Neuroblastoma Research and TreatmentsNeurofibromatosis and Schwannoma Cases

Cited by 116

PI3K-mTORC2 but not PI3K-mTORC1 regulates transcription of HIF2A/EPAS1 and vascularization in neuroblastoma

Mohlin, S., Hamidian, A., von Stedingk, K., Bridges, E., Wigerup, C., Bexell, D., & Påhlman, S. (2015) · Cancer Research

Cancer, Hypoxia, and MetabolismNeuroblastoma Research and Treatments

Cited by 104

HIF-1α and HIF-2α Are Differentially Regulated In vivo in Neuroblastoma: High HIF-1α Correlates Negatively to Advanced Clinical Stage and Tumor Vascularization

Noguera, R., Fredlund, E., Piqueras, M., Pietras, A., Beckman, S., Navarro, S., & Påhlman, S. (2009) · Clinical Cancer Research

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 78

HIF-2α expression in human fetal paraganglia and neuroblastoma: relation to sympathetic differentiation, glucose deficiency, and hypoxia

Nilsson, H., Jögi, A., Beckman, S., Harris, A. L., Poellinger, L., & Påhlman, S. (2005) · Experimental Cell Research

Neuroblastoma Research and TreatmentsCancer, Hypoxia, and Metabolism

Cited by 75

HIF2A and IGF2 expression correlates in human neuroblastoma cells and normal immature sympathetic neuroblasts

Mohlin, S., Hamidian, A., & Påhlman, S. (2013) · Neoplasia

Neuroblastoma Research and TreatmentsCancer, Hypoxia, and Metabolism

Cited by 49

ARNT-dependent HIF-2 transcriptional activity is not sufficient to regulate downstream target genes in neuroblastoma

Persson, C. U., von Stedingk, K., Fredlund, E., Bexell, D., Påhlman, S., Wigerup, C., & Mohlin, S. (2020) · Experimental Cell Research

Cancer, Hypoxia, and MetabolismNeuroblastoma Research and Treatments

Cited by 37

Myc-induced glutaminolysis bypasses HIF-driven glycolysis in hypoxic small cell lung carcinoma cells

Thorén, M. M., Vaapil, M., Staaf, J., Planck, M., Johansson, M. E., Mohlin, S., & Påhlman, S. (2017) · Oncotarget

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 31