Wykoff, Charles C.

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature

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Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials

Heier, J. S., Khanani, A. M., Quezada Ruiz, C., Basu, K., Ferrone, P. J., Brittain, C., Figueroa, M. S., Lin, H., Holz, F. G., Patel, V., et al. (2022) · The Lancet

Retinal Diseases and TreatmentsOcular Diseases and Behçet’s Syndrome

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HIF activation identifies early lesions in VHL kidneys

Mandriota, S. J., Turner, K. J., Davies, D. R., Murray, P. G., Morgan, N. V., Sowter, H. M., Wykoff, C. C., Maher, E. R., Harris, A. L., Ratcliffe, P. J., et al. (2002) · Cancer Cell

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

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Avacincaptad pegol for geographic atrophy secondary to age-related macular degeneration: 18-month findings from the GATHER1 trial

Patel, S. S., Lally, D. R., Hsu, J., Wykoff, C. C., Eichenbaum, D., Heier, J. S., Jaffe, G. J., Westby, K., Desai, D., Zhu, L., et al. (2023) · Eye

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Gene therapy for neovascular age-related macular degeneration by subretinal delivery of RGX-314: a phase 1/2a dose-escalation study

Campochiaro, P. A., Avery, R., Brown, D. M., Heier, J. S., Ho, A. C., Huddleston, S. M., Jaffe, G. J., Khanani, A. M., Pakola, S., Pieramici, D. J., et al. (2024) · The Lancet

Retinal Diseases and TreatmentsRetinal Development and Disorders

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DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer

Giatromanolaki, A., Koukourakis, M. I., Sivridis, E., Turley, H., Wykoff, C. C., Gatter, K. C., & Harris, A. L. (2003) · The Journal of Pathology

Cancer, Hypoxia, and MetabolismLung Cancer Research Studies

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Efficacy and Safety of Abicipar in Neovascular Age-Related Macular Degeneration

Kunimoto, D., Yoon, Y. H., Wykoff, C. C., Chang, A., Khurana, R. N., Maturi, R. K., Agostini, H., Souied, E., Chow, D. R., Lotery, A. J., et al. (2020) · Ophthalmology

Retinal Diseases and TreatmentsRetinal and Macular Surgery

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Safety and efficacy of ixoberogene soroparvovec in neovascular age-related macular degeneration in the United States (OPTIC): a prospective, two-year, multicentre phase 1 study

Khanani, A. M., Boyer, D. S., Wykoff, C. C., Regillo, C. D., Busbee, B. G., Pieramici, D., Danzig, C. J., Joondeph, B. C., Major, J. C., Turpcu, A., et al. (2024) · eClinicalMedicine

Retinal Diseases and TreatmentsRetinal Development and Disorders

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Suprachoroidal CLS-TA plus Intravitreal Aflibercept for Diabetic Macular Edema

Barakat, M. R., Wykoff, C. C., Gonzalez, V., Hu, A., Marcus, D., Zavaleta, E., & Ciulla, T. A. (2021) · Ophthalmology Retina

Retinal Diseases and TreatmentsRetinal and Macular Surgery

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Sensitivity analysis in clinical trials: three criteria for a valid sensitivity analysis

Parpia, S., Morris, T. P., Phillips, M. R., Wykoff, C. C., Steel, D. H., Thabane, L., Bhandari, M., Chaudhary, V., for the Retina Evidence Trials InterNational Alliance (R.E.T.I.N.A.) Study Group, Sivaprasad, S., et al. (2022) · Eye

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