Elkins, Jonathan M.

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

Hewitson, K. S., McNeill, L. A., Riordan, M. V., Tian, Y.-M., Bullock, A. N., Welford, R. W., Elkins, J. M., Oldham, N. J., Bhattacharya, S., Gleadle, J. M., et al. (2002) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 719

Structure of Factor-inhibiting Hypoxia-inducible Factor (HIF) Reveals Mechanism of Oxidative Modification of HIF-1α

Elkins, J. M., Hewitson, K. S., McNeill, L. A., Seibel, J. F., Schlemminger, I., Pugh, C. W., Ratcliffe, P. J., & Schofield, C. J. (2003) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 391

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

Zhang, T., Kwiatkowski, N., Olson, C. M., Dixon-Clarke, S. E., Abraham, B. J., Greifenberg, A. K., Ficarro, S. B., Elkins, J. M., Liang, Y., Hannett, N. M., et al. (2016) · Nature Chemical Biology

Protein Degradation and InhibitorsHeterocyclic Compound Synthesis and Bioactivity

Cited by 374

Comprehensive characterization of the Published Kinase Inhibitor Set

Elkins, J. M., Fedele, V., Szklarz, M., Abdul Azeez, K. R., Salah, E., Mikolajczyk, J., Romanov, S., Sepetov, N., Huang, X.-P., Roth, B. L., et al. (2016) · Nature Biotechnology

Computational Drug Discovery MethodsProtein Kinase Regulation and GTPase Signaling

Cited by 323

Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding

Dixon-Clarke, S. E., Elkins, J. M., Cheng, S.-W. G., Morin, G. B., & Bullock, A. N. (2015) · Scientific Reports

Protein Kinase Regulation and GTPase SignalingGenomics and Chromatin Dynamics

Cited by 38

Structural insights into cobalamin loading and reactivation of human methionine synthase

Ferreira, D. S. M., McLennan, K., Diamond, C., Vollmar, M., Kiyani, W., Froese, D. S., Kopec, J., Bailey, H. J., Chalk, R., Baslé, A., et al. (2026) · Nature Communications

Folate and B Vitamins ResearchEnzyme Structure and Function

Cited by 3

Amino acid and viral binding by the high-affinity Cationic Amino acid Transporter 1 (CAT1) from Mus musculus

Ye, M., Liang, Z., Zhou, D., Pike, A. C. W., Wang, S., Wang, D., Bakshi, S., Brooke, L., Williams, E. P., Elkins, J. M., et al. (2026) · Nature Communications

Amino Acid Enzymes and MetabolismEnzyme Structure and Function

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