Dekkers, Johanna F.

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

Schwank, G., Koo, B.-K., Sasselli, V., Dekkers, J. F., Heo, I., Demircan, T., Sasaki, N., Boymans, S., Cuppen, E., van der Ent, C. K., et al. (2013) · Cell Stem Cell

CRISPR and Genetic EngineeringCystic Fibrosis Research Advances

Cited by 1,424

Long‐term expanding human airway organoids for disease modeling

Sachs, N., Papaspyropoulos, A., Zomer‐van Ommen, D. D., Heo, I., Böttinger, L., Klay, D., Weeber, F., Huelsz‐Prince, G., Iakobachvili, N., Amatngalim, G. D., et al. (2019) · The EMBO Journal

Cystic Fibrosis Research AdvancesNeonatal Respiratory Health Research

Cited by 1,082

A functional CFTR assay using primary cystic fibrosis intestinal organoids

Dekkers, J. F., Wiegerinck, C. L., de Jonge, H. R., Bronsveld, I., Janssens, H. M., de Winter-de Groot, K. M., Brandsma, A. M., de Jong, N. W. M., Bijvelds, M. J. C., Scholte, B. J., et al. (2013) · Nature Medicine

Cystic Fibrosis Research AdvancesGenetic and Kidney Cyst Diseases

Cited by 999

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

Dekkers, J. F., Berkers, G., Kruisselbrink, E., Vonk, A., de Jonge, H. R., Janssens, H. M., Bronsveld, I., van de Graaf, E. A., Nieuwenhuis, E. E. S., Houwen, R. H. J., et al. (2016) · Science Translational Medicine

Cystic Fibrosis Research AdvancesGenetic and Kidney Cyst Diseases

Cited by 548

Mechanism-based corrector combination restores ΔF508-CFTR folding and function

Okiyoneda, T., Veit, G., Dekkers, J. F., Bagdany, M., Soya, N., Xu, H., Roldan, A., Verkman, A. S., Kurth, M., Simon, A., et al. (2013) · Nature Chemical Biology

Cystic Fibrosis Research AdvancesIon Transport and Channel Regulation

Cited by 378

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping

Gehart, H., van Es, J. H., Hamer, K., Beumer, J., Kretzschmar, K., Dekkers, J. F., Rios, A., & Clevers, H. (2019) · Cell

Single-cell and spatial transcriptomicsDevelopmental Biology and Gene Regulation

Cited by 346

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

Berkers, G., van Mourik, P., Vonk, A. M., Kruisselbrink, E., Dekkers, J. F., de Winter-de Groot, K. M., Arets, H. G. M., Marck-van der Wilt, R. E. P., Dijkema, J. S., Vanderschuren, M. M., et al. (2019) · Cell Reports

Cystic Fibrosis Research AdvancesTissue Engineering and Regenerative Medicine

Cited by 310

Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis

Alton, E. W. F. W., Beekman, J. M., Boyd, A. C., Brand, J., Carlon, M. S., Connolly, M. M., Chan, M., Conlon, S., Davidson, H. E., Davies, J. C., et al. (2017) · Thorax

Virus-based gene therapy researchCystic Fibrosis Research Advances

Cited by 150

Protocol for Application, Standardization and Validation of the Forskolin-Induced Swelling Assay in Cystic Fibrosis Human Colon Organoids

Vonk, A. M., van Mourik, P., Ramalho, A. S., Silva, I. A. L., Statia, M., Kruisselbrink, E., Suen, S. W. F., Dekkers, J. F., Vleggaar, F. P., Houwen, R. H. J., et al. (2020) · STAR Protocols

Cystic Fibrosis Research AdvancesGenetic and Kidney Cyst Diseases

Cited by 128

Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor-positive breast cancer

Whittle, J. R., Vaillant, F., Surgenor, E., Policheni, A. N., Giner, G., Capaldo, B. D., Chen, H.-R., Liu, H. K., Dekkers, J. F., Sachs, N., et al. (2020) · Clinical Cancer Research

Advanced Breast Cancer TherapiesBreast Cancer Treatment Studies

Cited by 102

rAAV-CFTRΔR Rescues the Cystic Fibrosis Phenotype in Human Intestinal Organoids and Cystic Fibrosis Mice

Vidović, D., Carlon, M. S., da Cunha, M. F., Dekkers, J. F., Hollenhorst, M. I., Bijvelds, M. J. C., Ramalho, A. S., Van den Haute, C., Ferrante, M., Baekelandt, V., et al. (2016) · American Journal of Respiratory and Critical Care Medicine

Cystic Fibrosis Research AdvancesVirus-based gene therapy research

Cited by 74