Langmann, Thomas

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

Fritsche, L. G., Igl, W., Bailey, J. N. C., Grassmann, F., Sengupta, S., Bragg-Gresham, J. L., Burdon, K. P., Hebbring, S. J., Wen, C., Gorski, M., et al. (2016) · Nature Genetics

Retinal Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 1,544

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

Bodzioch, M., Orsó, E., Klucken, J., Langmann, T., Böttcher, A., Diederich, W., Drobnik, W., Barlage, S., Büchler, C., Porsch-Özcürümez, M., et al. (1999) · Nature Genetics

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 1,512

Microglia activation in retinal degeneration

Langmann, T. (2007) · Journal of Leukocyte Biology

Neuroinflammation and Neurodegeneration MechanismsRetinal Development and Disorders

Cited by 496

CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors

Corbo, J. C., Lawrence, K. A., Karlstetter, M., Myers, C. A., Abdelaziz, M., Dirkes, W., Weigelt, K., Seifert, M., Benes, V., Fritsche, L. G., et al. (2010) · Genome Research

Retinal Development and DisordersGenomics and Chromatin Dynamics

Cited by 219

Microglia in the healthy and degenerating retina: Insights from novel mouse models

Karlstetter, M., Ebert, S., & Langmann, T. (2010) · Immunobiology

Neuroinflammation and Neurodegeneration MechanismsRetinal Development and Disorders

Cited by 197

Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration

Scholz, R., Sobotka, M., Caramoy, A., Stempfl, T., Moehle, C., & Langmann, T. (2015) · Journal of Neuroinflammation

Retinal Development and DisordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 177

Loss of IL-10 Promotes Differentiation of Microglia to a M1 Phenotype

Laffer, B., Bauer, D., Wasmuth, S., Busch, M., Jalilvand, T. V., Thanos, S., Meyer zu Hörste, G., Loser, K., Langmann, T., Heiligenhaus, A., et al. (2019) · Frontiers in Cellular Neuroscience

Neuroinflammation and Neurodegeneration MechanismsImmune cells in cancer

Cited by 120

Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration

Scholz, R., Caramoy, A., Bhuckory, M. B., Rashid, K., Chen, M., Xu, H., Grimm, C., & Langmann, T. (2015) · Journal of Neuroinflammation

Retinal Development and DisordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 111

The tspo-nox1 axis controls phagocyte-triggered pathological angiogenesis in the eye

Wolf, A., Herb, M., Schramm, M., & Langmann, T. (2020) · Nature Communications

Retinal Diseases and TreatmentsRetinal Imaging and Analysis

Cited by 80

A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration

Strunz, T., Lauwen, S., Kiel, C., International AMD Genomics Consortium (IAMDGC), Fritsche, L. G., Igl, W., Bailey, J. N. C., Grassmann, F., Sengupta, S., Bragg-Gresham, J. L., et al. (2020) · Scientific Reports

Genetic Associations and EpidemiologyRetinal Diseases and Treatments

Cited by 60

Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness, 9/2020

Chan, Y. K., Dick, A. D., Hall, S. M., Langmann, T., Scribner, C. L., Mansfield, B. C., & for the Ocular Gene Therapy Inflammation Working Group (2021) · Translational Vision Science & Technology

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 56

Human ATP-binding cassette transporter TaqMan low-density array: analysis of macrophage differentiation and foam cell formation

Langmann, T., Mauerer, R., & Schmitz, G. (2006) · Clinical Chemistry

Cholesterol and Lipid MetabolismDrug Transport and Resistance Mechanisms

Cited by 49

Indole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration

Khan, A. S., & Langmann, T. (2020) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsRetinal Development and Disorders

Cited by 44

Dap12 expression in activated microglia from retinoschisin-deficient retina and its PU.1-dependent promoter regulation

Weigelt, K., Ernst, W., Walczak, Y., Ebert, S., Loenhardt, T., Klug, M., Rehli, M., Weber, B. H. F., & Langmann, T. (2007) · Journal of Leukocyte Biology

Neuroinflammation and Neurodegeneration MechanismsRetinal Development and Disorders

Cited by 38