Saharinen, Pipsa

Therapeutic targeting of the angiopoietin–TIE pathway

Saharinen, P., Eklund, L., & Alitalo, K. (2017) · Nature Reviews Drug Discovery

Angiogenesis and VEGF in CancerLymphatic System and Diseases

Cited by 620

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

Saharinen, P., Eklund, L., Miettinen, J., Wirkkala, R., Anisimov, A., Winderlich, M., Nottebaum, A., Vestweber, D., Deutsch, U., Koh, G. Y., et al. (2008) · Nature Cell Biology

Angiogenesis and VEGF in CancerLymphatic System and Diseases

Cited by 471

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

Hakanpaa, L., Sipila, T., Leppanen, V.-M., Gautam, P., Nurmi, H., Jacquemet, G., Eklund, L., Ivaska, J., Alitalo, K., & Saharinen, P. (2015) · Nature Communications

Angiogenesis and VEGF in CancerCell Adhesion Molecules Research

Cited by 287

Tie1 controls angiopoietin function in vascular remodeling and inflammation

Korhonen, E. A., Lampinen, A., Giri, H., Anisimov, A., Kim, M., Allen, B., Fang, S., D’Amico, G., Sipilä, T. J., Lohela, M., et al. (2016) · Journal of Clinical Investigation

Angiogenesis and VEGF in CancerLymphatic System and Diseases

Cited by 283

Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell–Cell Junctions and Lung Metastasis

Holopainen, T., Saharinen, P., D’Amico, G., Lampinen, A., Eklund, L., Sormunen, R., Anisimov, A., Zarkada, G., Lohela, M., Heloterä, H., et al. (2012) · JNCI: Journal of the National Cancer Institute

Angiogenesis and VEGF in CancerLymphatic System and Diseases

Cited by 216

Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization

Leppänen, V.-M., Saharinen, P., & Alitalo, K. (2017) · Proceedings of the National Academy of Sciences

Angiogenesis and VEGF in CancerLymphatic System and Diseases

Cited by 127

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

Korhonen, E. A., Murtomäki, A., Jha, S. K., Anisimov, A., Pink, A., Zhang, Y., Stritt, S., Liaqat, I., Stanczuk, L., Alderfer, L., et al. (2022) · Journal of Clinical Investigation

Lymphatic System and DiseasesAngiogenesis and VEGF in Cancer

Cited by 113

Transcriptomal comparison of human dermal lymphatic endothelial cells ex vivo and in vitro

Wick, N., Saharinen, P., Saharinen, J., Gurnhofer, E., Steiner, C. W., Raab, I., Stokic, D., Giovanoli, P., Buchsbaum, S., Burchard, A., et al. (2007) · Physiological Genomics

Lymphatic System and DiseasesLymphatic Disorders and Treatments

Cited by 106

Targeting β1-integrin inhibits vascular leakage in endotoxemia

Hakanpaa, L., Kiss, E. A., Jacquemet, G., Miinalainen, I., Lerche, M., Guzmán, C., Mervaala, E., Eklund, L., Ivaska, J., & Saharinen, P. (2018) · Proceedings of the National Academy of Sciences

Cell Adhesion Molecules ResearchBarrier Structure and Function Studies

Cited by 95

Characterization of ANGPT2 mutations associated with primary lymphedema

Leppänen, V.-M., Brouillard, P., Korhonen, E. A., Sipilä, T., Jha, S. K., Revencu, N., Labarque, V., Fastré, E., Schlögel, M., Ravoet, M., et al. (2020) · Science Translational Medicine

Lymphatic System and DiseasesLymphatic Disorders and Treatments

Cited by 49

Endothelial Pim3 kinase protects the vascular barrier during lung metastasis

Santio, N. M., Ganesh, K., Kaipainen, P. P., Halme, A., Seyednasrollah, F., Arbash, E., Hänninen, S., Kivelä, R., Carpen, O., & Saharinen, P. (2024) · Nature Communications

Angiogenesis and VEGF in CancerCancer Cells and Metastasis

Cited by 9

Inactive β1-integrin acts as a junctional scaffold for angiopoietin/TIE2/FOXO1 signaling

Sipilä, T., Ponna, S. K., Venkatesha Murthy, A., Pink, A., Enkavi, G., Bohra, S. K., Lewna, K., Ganesh, K., Liu, Q., Korhonen, M., et al. (2026) · Journal of Clinical Investigation

Cell Adhesion Molecules ResearchAngiogenesis and VEGF in Cancer

Cited by 0