Kletsas, Dimitris

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

Gorgoulis, V. G., Vassiliou, L.-V. F., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., DiTullio, R. A., Kastrinakis, N. G., Levy, B., et al. (2005) · Nature

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 2,009

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L.-V. F., Kolettas, E., Niforou, K., Zoumpourlis, V. C., et al. (2006) · Nature

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 1,986

Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues

Georgakopoulou, E., Tsimaratou, K., Evangelou, K., Fernandez, M.-P., Zoumpourlis, V, Trougakos, I., Kletsas, D., Bartek, J., Serrano, M., & Gorgoulis, V. (2012) · Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 390

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

Galanos, P., Vougas, K., Walter, D., Polyzos, A., Maya-Mendoza, A., Haagensen, E. J., Kokkalis, A., Roumelioti, F.-M., Gagos, S., Tzetis, M., et al. (2016) · Nature Cell Biology

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 308

Senescence in human intervertebral discs

Roberts, S., Evans, E. H., Kletsas, D., Jaffray, D. C., & Eisenstein, S. M. (2006) · European Spine Journal

Spine and Intervertebral Disc PathologyTelomeres, Telomerase, and Senescence

Cited by 305

Robust, universal biomarker assay to detect senescent cells in biological specimens

Evangelou, K., Lougiakis, N., Rizou, S. V., Kotsinas, A., Kletsas, D., Muñoz‐Espín, D., Kastrinakis, N. G., Pouli, N., Marakos, P., Townsend, P., et al. (2017) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 259

Intracellular Clusterin Inhibits Mitochondrial Apoptosis by Suppressing p53-Activating Stress Signals and Stabilizing the Cytosolic Ku70-Bax Protein Complex

Trougakos, I. P., Lourda, M., Antonelou, M. H., Kletsas, D., Gorgoulis, V. G., Papassideri, I. S., Zou, Y., Margaritis, L. H., Boothman, D. A., & Gonos, E. S. (2009) · Clinical Cancer Research

Clusterin in disease pathologyCell death mechanisms and regulation

Cited by 160

Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis

Mavrogonatou, E., Pratsinis, H., Papadopoulou, A., Karamanos, N. K., & Kletsas, D. (2019) · Matrix Biology

Telomeres, Telomerase, and SenescenceCellular Mechanics and Interactions

Cited by 153

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

Velimezi, G., Liontos, M., Vougas, K., Roumeliotis, T., Bartkova, J., Sideridou, M., Dereli-Oz, A., Kocylowski, M., Pateras, I. S., Evangelou, K., et al. (2013) · Nature Cell Biology

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 131

p53-Dependent ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesions

Gorgoulis, V. G., Pratsinis, H., Zacharatos, P., Demoliou, C., Sigala, F., Asimacopoulos, P. J., Papavassiliou, A. G., & Kletsas, D. (2005) · Laboratory Investigation

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 122

Scarless wound healing: From development to senescence

Pratsinis, H., Mavrogonatou, E., & Kletsas, D. (2019) · Advanced Drug Delivery Reviews

Wound Healing and TreatmentsDermatologic Treatments and Research

Cited by 103