Torbett, Bruce E.

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities

McKercher, S. R., Torbett, B. E., Anderson, K. L., Henkel, G. W., Vestal, D. J., Baribault, H., Klemsz, M., Feeney, A. J., Wu, G. E., Paige, C. J., et al. (1996) · The EMBO Journal

Hematopoietic Stem Cell TransplantationT-cell and B-cell Immunology

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PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding

Zhang, P., Zhang, X., Iwama, A., Yu, C., Smith, K. A., Mueller, B. U., Narravula, S., Torbett, B. E., Orkin, S. H., & Tenen, D. G. (2000) · Blood

Genomics and Chromatin DynamicsHemoglobinopathies and Related Disorders

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Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor

Amirache, F., Lévy, C., Costa, C., Mangeot, P.-E., Torbett, B. E., Wang, C. X., Nègre, D., Cosset, F.-L., & Verhoeyen, E. (2014) · Blood

Virus-based gene therapy researchRNA Interference and Gene Delivery

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Myeloid Development Is Selectively Disrupted in PU.1 Null Mice

Anderson, K. L., Smith, K. A., Conners, K., McKercher, S. R., Maki, R. A., & Torbett, B. E. (1998) · Blood

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

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C/EBPα binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment

Yeamans, C., Wang, D., Paz-Priel, I., Torbett, B. E., Tenen, D. G., & Friedman, A. D. (2007) · Blood

Genomics and Chromatin DynamicsAcute Myeloid Leukemia Research

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Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichment

Yuan, J., Wang, J., Crain, K., Fearns, C., Kim, K. A., Hua, K. L., Gregory, P. D., Holmes, M. C., & Torbett, B. E. (2012) · Molecular Therapy

HIV Research and TreatmentCRISPR and Genetic Engineering

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PU.1 is a lineage-specific regulator of tyrosine phosphatase CD45

Anderson, K. L., Nelson, S. L., Perkin, H. B., Smith, K. A., Klemsz, M. J., & Torbett, B. E. (2001) · Journal of Biological Chemistry

Protein Tyrosine PhosphatasesGenomics and Chromatin Dynamics

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PU.1 binding to the p53 family of tumor suppressors impairs their transcriptional activity

Tschan, M. P., Reddy, V. A., Ress, A., Arvidsson, G., Fey, M. F., & Torbett, B. E. (2008) · Oncogene

Cancer-related Molecular PathwaysKruppel-like factors research

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Development of Lentiviral Vectors for HIV-1 Gene Therapy with Vif-Resistant APOBEC3G

Delviks-Frankenberry, K. A., Ackerman, D., Timberlake, N. D., Hamscher, M., Nikolaitchik, O. A., Hu, W.-S., Torbett, B. E., & Pathak, V. K. (2019) · Molecular Therapy Nucleic Acids

Virus-based gene therapy researchHIV Research and Treatment

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