Mani, Sridhar

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Vétizou, M., Pitt, J. M., Daillère, R., Lepage, P., Waldschmitt, N., Flament, C., Rusakiewicz, S., Routy, B., Roberti, M. P., Duong, C. P. M., et al. (2015) · Science

Cancer Immunotherapy and BiomarkersGut microbiota and health

Cited by 3,488

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

Wallace, B. D., Wang, H., Lane, K. T., Scott, J. E., Orans, J., Koo, J. S., Venkatesh, M., Jobin, C., Yeh, L.-A., Mani, S., et al. (2010) · Science

Pharmacogenetics and Drug MetabolismCancer therapeutics and mechanisms

Cited by 1,080

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4

Venkatesh, M., Mukherjee, S., Wang, H., Li, H., Sun, K., Benechet, A. P., Qiu, Z., Maher, L., Redinbo, M. R., Phillips, R. S., et al. (2014) · Immunity

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 1,066

Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens

Ervin, S. M., Li, H., Lim, L., Roberts, L. R., Liang, X., Mani, S., & Redinbo, M. R. (2019) · Journal of Biological Chemistry

Gut microbiota and healthEstrogen and related hormone effects

Cited by 397

Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity

Wallace, B. D., Roberts, A. B., Pollet, R. M., Ingle, J. D., Biernat, K. A., Pellock, S. J., Venkatesh, M. K., Guthrie, L., O’Neal, S. K., Robinson, S. J., et al. (2015) · Chemistry & Biology

Enzyme Structure and FunctionPharmacogenetics and Drug Metabolism

Cited by 285

Recent advances of highly selective CDK4/6 inhibitors in breast cancer

Xu, H., Yu, S., Liu, Q., Yuan, X., Mani, S., Pestell, R. G., & Wu, K. (2017) · Journal of Hematology & Oncology

Advanced Breast Cancer TherapiesBreast Cancer Treatment Studies

Cited by 168

Molecular Insights into Microbial β-Glucuronidase Inhibition to Abrogate CPT-11 Toxicity

Roberts, A. B., Wallace, B. D., Venkatesh, M. K., Mani, S., & Redinbo, M. R. (2013) · Molecular Pharmacology

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 140

Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-κB signaling pathway

Dou, W., Zhang, J., Zhang, E., Sun, A., Ding, L., Chou, G., Wang, Z., & Mani, S. (2013) · The Journal of Pharmacology and Experimental Therapeutics

Flavonoids in Medical ResearchInflammatory Bowel Disease

Cited by 111

Pregnane X receptor activation attenuates inflammation-associated intestinal epithelial barrier dysfunction by inhibiting cytokine-induced myosin light-chain kinase expression and c-Jun N-terminal kinase 1/2 activation

Garg, A., Zhao, A., Erickson, S. L., Mukherjee, S., Lau, A. J., Alston, L., Chang, T. K. H., Mani, S., & Hirota, S. A. (2016) · The Journal of Pharmacology and Experimental Therapeutics

Inflammatory Bowel DiseaseDrug Transport and Resistance Mechanisms

Cited by 82

Safety, pharmacokinetics, and activity of EZN‐2208, a novel conjugate of polyethylene glycol and SN38, in patients with advanced malignancies

Kurzrock, R., Goel, S., Wheler, J., Hong, D., Fu, S., Rezai, K., Morgan‐Linnell, S. K., Urien, S., Mani, S., Chaudhary, I., et al. (2012) · Cancer

Cancer therapeutics and mechanismsPharmacogenetics and Drug Metabolism

Cited by 50

Understanding and Modulating Mammalian-Microbial Communication for Improved Human Health

Mani, S., Boelsterli, U. A., & Redinbo, M. R. (2014) · Annual Review of Pharmacology and Toxicology

Gut microbiota and healthPharmacogenetics and Drug Metabolism

Cited by 48

Pregnane x receptor regulates pathogen-induced inflammation and host defense against an intracellular bacterial infection through Toll-like receptor 4

Qiu, Z., Cervantes, J. L., Cicek, B. B., Mukherjee, S., Venkatesh, M., Maher, L. A., Salazar, J. C., Mani, S., & Khanna, K. M. (2016) · Scientific Reports

Immune Response and InflammationImmune responses and vaccinations

Cited by 46