Hunkeler, Moritz

Small-molecule-induced polymerization triggers degradation of BCL6

Słabicki, M., Yoon, H., Koeppel, J., Nitsch, L., Roy Burman, S. S., Di Genua, C., Donovan, K. A., Sperling, A. S., Hunkeler, M., Tsai, J. M., et al. (2020) · Nature

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 270

Structural basis for regulation of human acetyl-CoA carboxylase

Hunkeler, M., Hagmann, A., Stuttfeld, E., Chami, M., Guri, Y., Stahlberg, H., & Maier, T. (2018) · Nature

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 229

Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases

Hunkeler, M., Jin, C. Y., & Fischer, E. S. (2023) · Science

Cell death mechanisms and regulationUbiquitin and proteasome pathways

Cited by 48

Polymerization of ZBTB transcription factors regulates chromatin occupancy

Park, P. M. C., Park, J., Brown, J., Hunkeler, M., Roy Burman, S. S., Donovan, K. A., Yoon, H., Nowak, R. P., Słabicki, M., Ebert, B. L., et al. (2024) · Molecular Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 22

Structural ubiquitin contributes to K48 linkage-specificity of the HECT ligase Tom1

Warner, K., Hunkeler, M., Baek, K., Schmoker, A., Roy Burman, S. S., Overwijn, D., Jin, C., Donovan, K. A., & Fischer, E. S. (2024) · Cell Reports

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 8