Burstein, Ezra

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling

McNally, K. E., Faulkner, R., Steinberg, F., Gallon, M., Ghai, R., Pim, D., Langton, P., Pearson, N., Danson, C. M., Nägele, H., et al. (2017) · Nature Cell Biology

Cellular transport and secretionAutophagy in Disease and Therapy

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CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

Bartuzi, P., Billadeau, D. D., Favier, R., Rong, S., Dekker, D., Fedoseienko, A., Fieten, H., Wijers, M., Levels, J. H., Huijkman, N., et al. (2016) · Nature Communications

Cholesterol and Lipid MetabolismCellular transport and secretion

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Deubiquitination of NF-κB by Ubiquitin-Specific Protease-7 promotes transcription

Colleran, A., Collins, P. E., O’Carroll, C., Ahmed, A., Mao, X., McManus, B., Kiely, P. A., Burstein, E., & Carmody, R. J. (2013) · Proceedings of the National Academy of Sciences

NF-κB Signaling PathwaysUbiquitin and proteasome pathways

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The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking

Fedoseienko, A., Wijers, M., Wolters, J. C., Dekker, D., Smit, M., Huijkman, N., Kloosterhuis, N., Klug, H., Schepers, A., Willems van Dijk, K., et al. (2018) · Circulation Research

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

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Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling

Singla, A., Fedoseienko, A., Giridharan, S. S. P., Overlee, B. L., Lopez, A., Jia, D., Song, J., Huff-Hardy, K., Weisman, L., Burstein, E., et al. (2019) · Nature Communications

Cellular transport and secretionAutophagy in Disease and Therapy

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An Alternative Splice Form of Mdm2 Induces p53-independent Cell Growth and Tumorigenesis

Steinman, H. A., Burstein, E., Lengner, C., Gosselin, J., Pihan, G., Duckett, C. S., & Jones, S. N. (2004) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysRNA Research and Splicing

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Structural organization of the retriever–CCC endosomal recycling complex

Boesch, D. J., Singla, A., Han, Y., Kramer, D. A., Liu, Q., Suzuki, K., Juneja, P., Zhao, X., Long, X., Medlyn, M. J., et al. (2024) · Nature Structural & Molecular Biology

Cellular transport and secretionAutophagy in Disease and Therapy

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Structural Organization of the Retriever-CCC Endosomal Recycling Complex

Boesch, D., Singla, A., Han, Y., Kramer, D., Liu, Q., Suzuki, K., Juneja, P., Zhao, X., Long, X., Medlyn, M., et al. (2023) · Nature Structural & Molecular Biology

Cellular transport and secretionAutophagy in Disease and Therapy

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Structural Organization of the Retriever-CCC Endosomal Recycling Complex

Boesch, D. J., Singla, A., Han, Y., Kramer, D. A., Liu, Q., Suzuki, K., Juneja, P., Zhao, X., Long, X., Medlyn, M. J., et al. (2023) · Nature Structural & Molecular Biology

Cellular transport and secretionAutophagy in Disease and Therapy

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A common variant in CCDC93 protects against myocardial infarction and cardiovascular mortality by regulating endosomal trafficking of low-density lipoprotein receptor

Rimbert, A., Dalila, N., Wolters, J. C., Huijkman, N., Smit, M., Kloosterhuis, N., Riemsma, M., van der Veen, Y., Singla, A., van Dijk, F., et al. (2020) · European Heart Journal

Lipoproteins and Cardiovascular HealthGenetic Associations and Epidemiology

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Structural basis for Retriever-SNX17 assembly and endosomal sorting

Singla, A., Boesch, D. J., Fung, H. Y. J., Ngoka, C., Enriquez, A. S., Song, R., Kramer, D. A., Han, Y., Banarer, E., Lemoff, A., et al. (2024) · Nature Communications

Cellular transport and secretionAutophagy in Disease and Therapy

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CCDC22 mutations that impair COMMD binding cause attenuated 3C/Ritscher-Schinzel syndrome

Singla, A., Rogers, C., Touma, M.-J., El-Najjar, Y., Colley, A., Boesch, D. J., Billadeau, D. D., Gecz, J., Chen, B., & Burstein, E. (2025) · BMC Medical Genomics

Cellular transport and secretionGenomics and Rare Diseases

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