Handy, Diane E.

Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

Lubos, E., Loscalzo, J., & Handy, D. E. (2011) · Antioxidants & Redox Signaling

Selenium in Biological SystemsRedox biology and oxidative stress

Cited by 1,280

Redox regulation of mitochondrial function

Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling

Redox biology and oxidative stressMitochondrial Function and Pathology

Cited by 588

Network-based approach to prediction and population-based validation of in silico drug repurposing

Cheng, F., Desai, R. J., Handy, D. E., Wang, R., Schneeweiss, S., Barabási, A.-L., & Loscalzo, J. (2018) · Nature Communications

Computational Drug Discovery MethodsBioinformatics and Genomic Networks

Cited by 552

High glucose inhibits glucose‐6‐phosphate dehydrogenase, leading to increased oxidative stress and β‐cell apoptosis

Zhang, Z., Liew, C. W., Handy, D. E., Zhang, Y., Leopold, J. A., Hu, J., Guo, L., Kulkarni, R. N., Loscalzo, J., & Stanton, R. C. (2010) · The FASEB Journal

Pancreatic function and diabetesRedox biology and oxidative stress

Cited by 226

A genome-wide positioning systems network algorithm for in silico drug repurposing

Cheng, F., Lu, W., Liu, C., Fang, J., Hou, Y., Handy, D. E., Wang, R., Zhao, Y., Yang, Y., Huang, J., et al. (2019) · Nature Communications

Computational Drug Discovery MethodsBioinformatics and Genomic Networks

Cited by 215

Glutathione Peroxidase-1 Regulates Mitochondrial Function to Modulate Redox-dependent Cellular Responses

Handy, D. E., Lubos, E., Yang, Y., Galbraith, J. D., Kelly, N., Zhang, Y.-Y., Leopold, J. A., & Loscalzo, J. (2009) · Journal of Biological Chemistry

Redox biology and oxidative stressSelenium in Biological Systems

Cited by 187

Glutathione Peroxidase-3 Deficiency Promotes Platelet-Dependent Thrombosis In Vivo

Jin, R. C., Mahoney, C. E., (Coleman) Anderson, L., Ottaviano, F., Croce, K., Leopold, J. A., Zhang, Y.-Y., Tang, S.-S., Handy, D. E., & Loscalzo, J. (2011) · Circulation

Platelet Disorders and TreatmentsBlood Coagulation and Thrombosis Mechanisms

Cited by 186