Williams, David A.

Mouse model of x-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

Pollock, J. D., Williams, D. A., Gifford, M. A. C., Li, L. L., Du, X., Fisherman, J., Orkin, S. H., Doerschuk, C. M., & Dinauer, M. C. (1995) · Nature Genetics

Neutrophil, Myeloperoxidase and Oxidative MechanismsImmunodeficiency and Autoimmune Disorders

Cited by 921

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

Walter, D., Lier, A., Geiselhart, A., Thalheimer, F. B., Huntscha, S., Sobotta, M. C., Moehrle, B., Brocks, D., Bayindir, I., Kaschutnig, P., et al. (2015) · Nature

Hematopoietic Stem Cell TransplantationDNA Repair Mechanisms

Cited by 619

Hematopoietic stem-cell gene therapy for cerebral adrenoleukodystrophy

Eichler, F., Duncan, C., Musolino, P. L., Orchard, P. J., De Oliveira, S., Thrasher, A. J., Armant, M., Dansereau, C., Lund, T. C., Miller, W. P., et al. (2017) · New England Journal of Medicine

Virus-based gene therapy researchLysosomal Storage Disorders Research

Cited by 604

Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense

Roberts, A. W., Kim, C., Zhen, L., Lowe, J. B., Kapur, R., Petryniak, B., Spaetti, A., Pollock, J. D., Borneo, J. B., Bradford, G. B., et al. (1999) · Immunity

Neutrophil, Myeloperoxidase and Oxidative MechanismsProtein Kinase Regulation and GTPase Signaling

Cited by 556

Highly efficient therapeutic gene editing of human hematopoietic stem cells

Wu, Y., Zeng, J., Roscoe, B. P., Liu, P., Yao, Q., Lazzarotto, C. R., Clement, K., Cole, M. A., Luk, K., Baricordi, C., et al. (2019) · Nature Medicine

Hemoglobinopathies and Related DisordersCRISPR and Genetic Engineering

Cited by 515

Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease

Esrick, E. B., Lehmann, L. E., Biffi, A., Achebe, M., Brendel, C., Ciuculescu, M. F., Daley, H., MacKinnon, B., Morris, E., Federico, A., et al. (2021) · New England Journal of Medicine

Hemoglobinopathies and Related DisordersVirus-based gene therapy research

Cited by 449

A Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency

Hacein-Bey-Abina, S., Pai, S.-Y., Gaspar, H. B., Armant, M., Berry, C. C., Blanche, S., Bleesing, J., Blondeau, J., de Boer, H., Buckland, K. F., et al. (2014) · New England Journal of Medicine

Virus-based gene therapy researchImmunodeficiency and Autoimmune Disorders

Cited by 412

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

Townsend, E. C., Murakami, M. A., Christodoulou, A., Christie, A. L., Köster, J., DeSouza, T. A., Morgan, E. A., Kallgren, S. P., Liu, H., Wu, S.-C., et al. (2016) · Cancer Cell

Acute Lymphoblastic Leukemia researchAcute Myeloid Leukemia Research

Cited by 295

Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype.

Brendel, C., Guda, S., Renella, R., Bauer, D. E., Canver, M. C., Kim, Y.-J., Heeney, M. M., Klatt, D., Fogel, J., Milsom, M. D., et al. (2016) · Journal of Clinical Investigation

Hemoglobinopathies and Related DisordersVirus-based gene therapy research

Cited by 167

Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections

Crequer, A., Troeger, A., Patin, E., Ma, C. S., Picard, C., Pedergnana, V., Fieschi, C., Lim, A., Abhyankar, A., Gineau, L., et al. (2012) · Journal of Clinical Investigation

Immunodeficiency and Autoimmune DisordersT-cell and B-cell Immunology

Cited by 159

CTC1 Mutations in a patient with dyskeratosis congenita

Keller, R. B., Gagne, K. E., Usmani, G. N., Asdourian, G. K., Williams, D. A., Hofmann, I., & Agarwal, S. (2012) · Pediatric Blood & Cancer

Telomeres, Telomerase, and SenescenceBlood disorders and treatments

Cited by 138

RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development

Gu, Y., Chae, H.-D., Siefring, J. E., Jasti, A. C., Hildeman, D. A., & Williams, D. A. (2006) · Nature Immunology

T-cell and B-cell ImmunologyProtein Kinase Regulation and GTPase Signaling

Cited by 110

Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells

Chae, H.-D., Lee, K. E., Williams, D. A., & Gu, Y. (2008) · Blood

Protein Kinase Regulation and GTPase SignalingChemokine receptors and signaling

Cited by 81

The public repository of xenografts enables discovery and randomized phase II-like trials in mice

Townsend, E. C., Murakami, M. A., Christodoulou, A., Christie, A. L., Köster, J., DeSouza, T. A., Morgan, E. A., Kallgren, S. P., Liu, H., Wu, S.-C., et al. (2016) · Cancer Cell

Acute Lymphoblastic Leukemia researchAcute Myeloid Leukemia Research

Cited by 80

The changing face of adrenoleukodystrophy

Zhu, J., Eichler, F., Biffi, A., Duncan, C. N., Williams, D. A., & Majzoub, J. A. (2020) · Endocrine Reviews

Metabolism and Genetic DisordersLysosomal Storage Disorders Research

Cited by 78

Preclinical evaluation of a novel lentiviral vector driving lineage-specific BCL11A knockdown for sickle cell gene therapy

Brendel, C., Negre, O., Rothe, M., Guda, S., Parsons, G., Harris, C., McGuinness, M., Abriss, D., Tsytsykova, A., Klatt, D., et al. (2020) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchHemoglobinopathies and Related Disorders

Cited by 72

RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling

Chae, H.-D., Siefring, J. E., Hildeman, D. A., Gu, Y., & Williams, D. A. (2010) · PLoS ONE

T-cell and B-cell ImmunologyProtein Kinase Regulation and GTPase Signaling

Cited by 35

Scale-up and manufacturing of clinical-grade self-inactivating γ-retroviral vectors by transient transfection

van der Loo, J. C. M., Swaney, W. P., Grassman, E., Terwilliger, A., Higashimoto, T., Schambach, A., Baum, C., Thrasher, A. J., Williams, D. A., Nordling, D. L., et al. (2012) · Gene Therapy

Virus-based gene therapy researchViral Infectious Diseases and Gene Expression in Insects

Cited by 34

Hematopoietic stem-cell gene therapy is associated with restored white matter microvascular function in cerebral adrenoleukodystrophy

Lauer, A., Speroni, S. L., Choi, M., Da, X., Duncan, C., McCarthy, S., Krishnan, V., Lusk, C. A., Rohde, D., Hansen, M. B., et al. (2023) · Nature Communications

Virus-based gene therapy researchLysosomal Storage Disorders Research

Cited by 26

RhoH GTPase: A Key Regulator of Hematopoietic Cell Proliferation and Apoptosis?

Gu, Y., Zheng, Y., & Williams, D. A. (2005) · Cell Cycle

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 20

Leukemic survival factor SALL4 contributes to defective DNA damage repair

Wang, F., Gao, C., Lu, J., Tatetsu, H., Williams, D. A., Müller, L. U., Cui, W., & Chai, L. (2016) · Oncogene

DNA Repair MechanismsAcute Myeloid Leukemia Research

Cited by 17