Overkleeft, Herman S.

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

van Esbroeck, A. C. M., Janssen, A. P. A., Cognetta, A. B., Ogasawara, D., Shpak, G., van der Kroeg, M., Kantae, V., Baggelaar, M. P., de Vrij, F. M. S., Deng, H., et al. (2017) · Science

Cannabis and Cannabinoid ResearchComputational Drug Discovery Methods

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Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway

Altun, M., Besche, H. C., Overkleeft, H. S., Piccirillo, R., Edelmann, M. J., Kessler, B. M., Goldberg, A. L., & Ulfhake, B. (2010) · Journal of Biological Chemistry

Muscle Physiology and DisordersUbiquitin and proteasome pathways

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Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic β-subunits

Kessler, B. M., Tortorella, D., Altun, M., Kisselev, A. F., Fiebiger, E., Hekking, B. G., Ploegh, H. L., & Overkleeft, H. S. (2001) · Chemistry & Biology

Ubiquitin and proteasome pathwaysProtease and Inhibitor Mechanisms

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Activity-based protein profiling: an enabling technology in chemical biology research

Li, N., Overkleeft, H. S., & Florea, B. I. (2012) · Current Opinion in Chemical Biology

Click Chemistry and ApplicationsEnzyme function and inhibition

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Combinatorial assembly and design of enzymes

Lipsh-Sokolik, R., Khersonsky, O., Schröder, S. P., de Boer, C., Hoch, S.-Y., Davies, G. J., Overkleeft, H. S., & Fleishman, S. J. (2023) · Science

Protein Structure and DynamicsEnzyme Catalysis and Immobilization

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Simplified Monopalmitoyl Toll‐like Receptor 2 Ligand Mini‐UPam for Self‐Adjuvanting Neoantigen‐Based Synthetic Cancer Vaccines

van den Ende, T. C., Heuts, J. M. M., Gential, G. P. P., Visser, M., van de Graaff, M. J., Ho, N. I., Jiskoot, W., Valentijn, A. R. P. M., Meeuwenoord, N. J., Overkleeft, H. S., et al. (2021) · ChemBioChem

Immunotherapy and Immune ResponsesChemical Synthesis and Analysis

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