Denko, Nicholas C.

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 2,267

Hypoxia, HIF1 and glucose metabolism in the solid tumour

Denko, N. C. (2008) · Nature Reviews Cancer

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 1,707

FoxO3 Regulates Neural Stem Cell Homeostasis

Renault, V. M., Rafalski, V. A., Morgan, A. A., Salih, D. A. M., Brett, J. O., Webb, A. E., Villeda, S. A., Thekkat, P. U., Guillerey, C., Denko, N. C., et al. (2009) · Cell Stem Cell

Neurogenesis and neuroplasticity mechanismsFOXO transcription factor regulation

Cited by 586

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

Papandreou, I., Denko, N. C., Olson, M., Van Melckebeke, H., Lust, S., Tam, A., Solow-Cordero, D. E., Bouley, D. M., Offner, F., Niwa, M., et al. (2011) · Blood

Endoplasmic Reticulum Stress and DiseaseMultiple Myeloma Research and Treatments

Cited by 489

Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth

Sun, R. C., & Denko, N. C. (2014) · Cell Metabolism

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 344

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L

Papandreou, I., Lim, A. L., Laderoute, K., & Denko, N. C. (2008) · Cell Death & Differentiation

Autophagy in Disease and TherapyCancer, Hypoxia, and Metabolism

Cited by 334

Role of Prolyl Hydroxylation in Oncogenically Stabilized Hypoxia-inducible Factor-1α

Chan, D. A., Sutphin, P. D., Denko, N. C., & Giaccia, A. J. (2002) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 264

Hypoxia induces a novel signature of chromatin modifications and global repression of transcription

Johnson, A. B., Denko, N., & Barton, M. C. (2008) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Genomics and Chromatin DynamicsCancer, Hypoxia, and Metabolism

Cited by 250

β-Catenin Regulates Hepatic Mitochondrial Function and Energy Balance in Mice

Lehwald, N., Tao, G., Jang, K. Y., Papandreou, I., Liu, B., Liu, B., Pysz, M. A., Willmann, J. K., Knoefel, W. T., Denko, N. C., et al. (2012) · Gastroenterology

Mitochondrial Function and PathologyWnt/β-catenin signaling in development and cancer

Cited by 102

A Multimodal Data Analysis Approach for Targeted Drug Discovery Involving Topological Data Analysis (TDA)

Alagappan, M., Jiang, D., Denko, N., & Koong, A. C. (2016) · Advances in Experimental Medicine and Biology

Computational Drug Discovery MethodsTopological and Geometric Data Analysis

Cited by 10