Crook, Tim

DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis

Crighton, D., Wilkinson, S., O'Prey, J., Syed, N., Smith, P., Harrison, P. R., Gasco, M., Garrone, O., Crook, T., & Ryan, K. M. (2006) · Cell

Autophagy in Disease and TherapyCancer-related Molecular Pathways

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ASPP Proteins Specifically Stimulate the Apoptotic Function of p53

Samuels-Lev, Y., O'Connor, D. J., Bergamaschi, D., Trigiante, G., Hsieh, J.-K., Zhong, S., Campargue, I., Naumovski, L., Crook, T., & Lu, X. (2001) · Molecular Cell

Cancer-related Molecular PathwaysCell death mechanisms and regulation

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Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer

Delage, B., Fennell, D. A., Nicholson, L., McNeish, I., Lemoine, N. R., Crook, T., & Szlosarek, P. W. (2010) · International Journal of Cancer

Bacterial Cancer TherapyAmino Acid Enzymes and Metabolism

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Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer

Nicholson, L. J., Smith, P. R., Hiller, L., Szlosarek, P. W., Kimberley, C., Sehouli, J., Koensgen, D., Mustea, A., Schmid, P., & Crook, T. (2009) · International Journal of Cancer

Ovarian cancer diagnosis and treatmentEpigenetics and DNA Methylation

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Concomitant inactivation of p53 and Chk2 in breast cancer

Sullivan, A., Yuille, M., Repellin, C., Reddy, A., Reelfs, O., Bell, A., Dunne, B., Gusterson, B. A., Osin, P., Farrell, P. J., et al. (2002) · Oncogene

Cancer-related Molecular PathwaysBRCA gene mutations in cancer

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