Cantley, Lewis C.

The erbB3 gene product is a receptor for heregulin.

Carraway, K. L., Sliwkowski, M. X., Akita, R., Platko, J. V., Guy, P. M., Nuijens, A., Diamonti, A. J., Vandlen, R. L., Cantley, L. C., & Cerione, R. A. (1994) · Journal of Biological Chemistry

HER2/EGFR in Cancer ResearchBiotin and Related Studies

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Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

Mullarky, E., Lucki, N. C., Beheshti Zavareh, R., Anglin, J. L., Gomes, A. P., Nicolay, B. N., Wong, J. C. Y., Christen, S., Takahashi, H., Singh, P. K., et al. (2016) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

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Phosphatidylinositol 3-kinase, growth disorders, and cancer

Goncalves, M. D., Hopkins, B. D., & Cantley, L. C. (2018) · New England Journal of Medicine

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

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The carbohydrate-insulin model: A physiological perspective on the obesity pandemic

Ludwig, D. S., Aronne, L. J., Astrup, A., de Cabo, R., Cantley, L. C., Friedman, M. I., Heymsfield, S. B., Johnson, J. D., King, J. C., Krauss, R. M., et al. (2021) · The American Journal of Clinical Nutrition

Regulation of Appetite and ObesityDiet, Metabolism, and Disease

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Dietary fructose improves intestinal cell survival and nutrient absorption

Taylor, S. R., Ramsamooj, S., Liang, R. J., Katti, A., Pozovskiy, R., Vasan, N., Hwang, S.-K., Nahiyaan, N., Francoeur, N. J., Schatoff, E. M., et al. (2021) · Nature

Diet, Metabolism, and DiseaseMetabolism, Diabetes, and Cancer

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Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer

Hopkins, B. D., Goncalves, M. D., & Cantley, L. C. (2020) · Nature Reviews Endocrinology

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

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Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size

Saci, A., Cantley, L. C., & Carpenter, C. L. (2011) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

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Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

Wei, S., Kozono, S., Kats, L., Nechama, M., Li, W., Guarnerio, J., Luo, M., You, M.-H., Yao, Y., Kondo, A., et al. (2015) · Nature Medicine

Signaling Pathways in DiseaseRetinoids in leukemia and cellular processes

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Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial

Konstantinopoulos, P. A., Barry, W. T., Birrer, M., Westin, S. N., Cadoo, K. A., Shapiro, G. I., Mayer, E. L., O'Cearbhaill, R. E., Coleman, R. L., Kochupurakkal, B., et al. (2019) · The Lancet Oncology

PARP inhibition in cancer therapyBRCA gene mutations in cancer

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Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

Lien, E. C., Lyssiotis, C. A., Juvekar, A., Hu, H., Asara, J. M., Cantley, L. C., & Toker, A. (2016) · Nature Cell Biology

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

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Age-induced accumulation of methylmalonic acid promotes tumour progression

Gomes, A. P., Ilter, D., Low, V., Endress, J. E., Fernández-García, J., Rosenzweig, A., Schild, T., Broekaert, D., Ahmed, A., Planque, M., et al. (2020) · Nature

Cancer, Lipids, and MetabolismGenetics, Aging, and Longevity in Model Organisms

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Biomolecular Characterization and Protein Sequences of the Campanian Hadrosaur B. canadensis

Schweitzer, M. H., Zheng, W., Organ, C. L., Avci, R., Suo, Z., Freimark, L. M., Lebleu, V. S., Duncan, M. B., Vander Heiden, M. G., Neveu, J. M., et al. (2009) · Science

Paleontology and Evolutionary BiologyEvolution and Paleontology Studies

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Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex

Kim, S. G., Hoffman, G. R., Poulogiannis, G., Buel, G. R., Jang, Y. J., Lee, K. W., Kim, B.-Y., Erikson, R. L., Cantley, L. C., Choo, A. Y., et al. (2013) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

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Use of RNA Interference-mediated Gene Silencing and Adenoviral Overexpression to Elucidate the Roles of AKT/Protein Kinase B Isoforms in Insulin Actions

Katome, T., Obata, T., Matsushima, R., Masuyama, N., Cantley, L. C., Gotoh, Y., Kishi, K., Shiota, H., & Ebina, Y. (2003) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

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Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers

Ebi, H., Corcoran, R. B., Singh, A., Chen, Z., Song, Y., Lifshits, E., Ryan, D. P., Meyerhardt, J. A., Benes, C., Settleman, J., et al. (2011) · Journal of Clinical Investigation

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Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

Mauvais-Jarvis, F., Ueki, K., Fruman, D. A., Hirshman, M. F., Sakamoto, K., Goodyear, L. J., Iannacone, M., Accili, D., Cantley, L. C., & Kahn, C. R. (2002) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

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Small molecule activation of PKM2 in cancer cells induces serine auxotrophy

Kung, C., Hixon, J., Choe, S., Marks, K., Gross, S., Murphy, E., DeLaBarre, B., Cianchetta, G., Sethumadhavan, S., Wang, X., et al. (2012) · Chemistry & Biology

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

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Utilization of Oriented Peptide Libraries to Identify Substrate Motifs Selected by ATM

O'Neill, T., Dwyer, A. J., Ziv, Y., Chan, D. W., Lees-Miller, S. P., Abraham, R. H., Lai, J. H., Hill, D., Shiloh, Y., Cantley, L. C., et al. (2000) · Journal of Biological Chemistry

DNA Repair MechanismsProtein Kinase Regulation and GTPase Signaling

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A Multi-enzyme Cascade of Hemoglobin Proteolysis in the Intestine of Blood-feeding Hookworms

Williamson, A. L., Lecchi, P., Turk, B. E., Choe, Y., Hotez, P. J., McKerrow, J. H., Cantley, L. C., Sajid, M., Craik, C. S., & Loukas, A. (2004) · Journal of Biological Chemistry

Parasites and Host InteractionsHelminth infection and control

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What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-Kinase Pathway

Klempner, S. J., Myers, A. P., & Cantley, L. C. (2013) · Cancer Discovery

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

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PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition

Mathur, D., Stratikopoulos, E., Ozturk, S., Steinbach, N., Pegno, S., Schoenfeld, S., Yong, R., Murty, V. V., Asara, J. M., Cantley, L. C., et al. (2017) · Cancer Discovery

Biochemical and Molecular ResearchCancer, Hypoxia, and Metabolism

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Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin

Liang, W.-W., Lu, R. J.-H., Jayasinghe, R. G., Foltz, S. M., Porta-Pardo, E., Geffen, Y., Wendl, M. C., Lazcano, R., Kolodziejczak, I., Song, Y., et al. (2023) · Cancer Cell

Epigenetics and DNA MethylationCancer Genomics and Diagnostics

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Altered propionate metabolism contributes to tumour progression and aggressiveness

Gomes, A. P., Ilter, D., Low, V., Drapela, S., Schild, T., Mullarky, E., Han, J., Elia, I., Broekaert, D., Rosenzweig, A., et al. (2022) · Nature Metabolism

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

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MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer

Shukla, S. K., Purohit, V., Mehla, K., Gunda, V., Chaika, N. V., Vernucci, E., King, R. J., Abrego, J., Goode, G. D., Dasgupta, A., et al. (2017) · Cancer Cell

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

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