Havens, Courtney G.
Celgene Corporation, 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States
5 papers on CoChat
Most cited papers
- Verified
Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate Tcells by inducing degradation of Tcell repressors Ikaros and Aiolos via modulation of the E 3 ubiquitin ligase complex CRL 4 CRBN
Gandhi, A. K., Kang, J., Havens, C. G., Conklin, T., Ning, Y., Wu, L., Ito, T., Ando, H., Waldman, M. F., Thakurta, A., et al. (2014) · British Journal of Haematology
Protein Degradation and InhibitorsUbiquitin and proteasome pathways
Cited by 619
- Verified
Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma
Hansen, J. D., Correa, M., Nagy, M. A., Alexander, M., Plantevin, V., Grant, V., Whitefield, B., Huang, D., Kercher, T., Harris, R., et al. (2020) · Journal of Medicinal Chemistry
Protein Degradation and InhibitorsMultiple Myeloma Research and Treatments
Cited by 240
- Verified
Rate of CRL4CRBN substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4
Bjorklund, C. C., Lu, L., Kang, J., Hagner, P. R., Havens, C. G., Amatangelo, M., Wang, M., Ren, Y., Couto, S., Breider, M., et al. (2015) · Blood Cancer Journal
Multiple Myeloma Research and TreatmentsProtein Degradation and Inhibitors
Cited by 221
- Verified
CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL
Hagner, P. R., Man, H.-W., Fontanillo, C., Wang, M., Couto, S., Breider, M., Bjorklund, C., Havens, C. G., Lu, G., Rychak, E., et al. (2015) · Blood
Protein Degradation and InhibitorsLymphoma Diagnosis and Treatment
Cited by 203
- Verified
CC-92480 Is a Novel Cereblon E3 Ligase Modulator with Enhanced Tumoricidal and Immunomodulatory Activity Against Sensitive and Resistant Multiple Myeloma Cells
Lopez-Girona, A., Havens, C. G., Lu, G., Rychak, E., Mendy, D., Gaffney, B., Surka, C., Lu, C.-C., Matyskiela, M., Khambatta, G., et al. (2019) · Blood
Protein Degradation and InhibitorsMultiple Myeloma Research and Treatments
Cited by 25
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