Dooley, Steven

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 1,280

TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019

Dewidar, B., Meyer, C., Dooley, S., & Meindl-Beinker, A. N. (2019) · Cells

Liver physiology and pathologyTGF-β signaling in diseases

Cited by 837

TGF-β in progression of liver disease

Dooley, S., & ten Dijke, P. (2012) · Cell and Tissue Research

Liver physiology and pathologyTGF-β signaling in diseases

Cited by 718

TGF‐β signalling and liver disease

Fabregat, I., Moreno‐Càceres, J., Sánchez, A., Dooley, S., Dewidar, B., Giannelli, G., ten Dijke, P., & the IT‐LIVER Consortium (2016) · The FEBS Journal

Liver physiology and pathologyTGF-β signaling in diseases

Cited by 600

Adverse outcome pathways: opportunities, limitations and open questions

Leist, M., Ghallab, A., Graepel, R., Marchan, R., Hassan, R., Bennekou, S. H., Limonciel, A., Vinken, M., Schildknecht, S., Waldmann, T., et al. (2017) · Archives of Toxicology

Animal testing and alternativesAgricultural safety and regulations

Cited by 394

Transforming Growth Factor-β (TGF-β)-mediated Connective Tissue Growth Factor (CTGF) Expression in Hepatic Stellate Cells Requires Stat3 Signaling Activation

Liu, Y., Liu, H., Meyer, C., Li, J., Nadalin, S., Königsrainer, A., Weng, H., Dooley, S., & ten Dijke, P. (2013) · Journal of Biological Chemistry

Liver physiology and pathologyTGF-β signaling in diseases

Cited by 181

IFN-γ abrogates profibrogenic TGF-β signaling in liver by targeting expression of inhibitory and receptor Smads

Weng, H., Mertens, P. R., Gressner, A. M., & Dooley, S. (2007) · Journal of Hepatology

Liver physiology and pathologyTGF-β signaling in diseases

Cited by 152

Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways

Klingmüller, U., Bauer, A., Bohl, S., Nickel, P. J., Breitkopf, K., Dooley, S., Zellmer, S., Kern, C., Merfort, I., Sparna, T., et al. (2006) · IEE Proceedings - Systems Biology

Liver physiology and pathologyGene Regulatory Network Analysis

Cited by 127

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood

Ghallab, A., Hofmann, U., Sezgin, S., Vartak, N., Hassan, R., Zaza, A., Godoy, P., Schneider, K. M., Guenther, G., Ahmed, Y. A., et al. (2019) · Hepatology

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 101

Glucocorticoids decrease the bioavailability of TGF-β which leads to a reduced TGF-β signaling in hepatic stellate cells

Bolkenius, U., Hahn, D., Gressner, A. M., Breitkopf, K., Dooley, S., & Wickert, L. (2004) · Biochemical and Biophysical Research Communications

Liver physiology and pathologyTGF-β signaling in diseases

Cited by 54

Vitamin D modulates biliary fibrosis in ABCB4-deficient mice

Hochrath, K., Stokes, C. S., Geisel, J., Pollheimer, M. J., Fickert, P., Dooley, S., & Lammert, F. (2014) · Hepatology International

Liver Diseases and ImmunityLiver physiology and pathology

Cited by 36