Shacter, Emily

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues

Chen, Q., Espey, M. G., Krishna, M. C., Mitchell, J. B., Corpe, C. P., Buettner, G. R., Shacter, E., & Levine, M. (2005) · Proceedings of the National Academy of Sciences

Vitamin C and Antioxidants ResearchCancer and biochemical research

Cited by 1,075

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo

Chen, Q., Espey, M. G., Sun, A. Y., Lee, J.-H., Krishna, M. C., Shacter, E., Choyke, P. L., Pooput, C., Kirk, K. L., Buettner, G. R., et al. (2007) · Proceedings of the National Academy of Sciences

Vitamin C and Antioxidants ResearchRedox biology and oxidative stress

Cited by 676

The Antioxidant Transcription Factor Nrf2 Negatively Regulates Autophagy and Growth Arrest Induced by the Anticancer Redox Agent Mitoquinone

Rao, V. A., Klein, S. R., Bonar, S. J., Zielonka, J., Mizuno, N., Dickey, J. S., Keller, P. W., Joseph, J., Kalyanaraman, B., & Shacter, E. (2010) · Journal of Biological Chemistry

Genomics, phytochemicals, and oxidative stressBioactive Compounds and Antitumor Agents

Cited by 139

Rac1 Inhibits Apoptosis in Human Lymphoma Cells by Stimulating Bad Phosphorylation on Ser-75

Zhang, B., Zhang, Y., & Shacter, E. (2004) · Molecular and Cellular Biology

Cell death mechanisms and regulationProtein Kinase Regulation and GTPase Signaling

Cited by 69

Mito-Tempol and Dexrazoxane Exhibit Cardioprotective and Chemotherapeutic Effects through Specific Protein Oxidation and Autophagy in a Syngeneic Breast Tumor Preclinical Model

Dickey, J. S., Gonzalez, Y., Aryal, B., Mog, S., Nakamura, A. J., Redon, C. E., Baxa, U., Rosen, E., Cheng, G., Zielonka, J., et al. (2013) · PLoS ONE

Chemotherapy-induced cardiotoxicity and mitigationBioactive Compounds and Antitumor Agents

Cited by 60