Chan, Ying Kai

Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses

Chan, Y. K., Wang, S. K., Chu, C. J., Copland, D. A., Letizia, A. J., Costa Verdera, H., Chiang, J. J., Sethi, M., Wang, M. K., Neidermyer, W. J., et al. (2021) · Science Translational Medicine

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 215

Adeno-Associated Virus (AAV) Versus Immune Response

Rabinowitz, J., Chan, Y. K., & Samulski, R. J. (2019) · Viruses

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 122

Management of neuroinflammatory responses to AAV-mediated gene therapies for neurodegenerative diseases

Perez, B. A., Shutterly, A., Chan, Y. K., Byrne, B. J., & Corti, M. (2020) · Brain Sciences

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 112

Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness, 9/2020

Chan, Y. K., Dick, A. D., Hall, S. M., Langmann, T., Scribner, C. L., Mansfield, B. C., & for the Ocular Gene Therapy Inflammation Working Group (2021) · Translational Vision Science & Technology

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 56

Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity

Xiao, Y., Muhuri, M., Li, S., Qin, W., Xu, G., Luo, L., Li, J., Letizia, A. J., Wang, S. K., Chan, Y. K., et al. (2019) · JCI Insight

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 53

AAV vectors trigger DNA damage response-dependent pro-inflammatory signalling in human iPSC-derived CNS models and mouse brain

Costa-Verdera, H., Meneghini, V., Fitzpatrick, Z., Abou Alezz, M., Fabyanic, E., Huang, X., Dzhashiashvili, Y., Ahiya, A., Mangiameli, E., Valeri, E., et al. (2025) · Nature Communications

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 32

Characterization of the ocular inflammatory response to AAV reveals divergence by sex and age

Clare, A. J., Langer, P. M., Ward, A., Chan, Y. K., Dick, A. D., & Copland, D. A. (2025) · Molecular Therapy

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 19

Enabling multiplexed testing of pooled donor cells through whole-genome sequencing

Chan, Y., Chan, Y. K., Goodman, D. B., Guo, X., Chavez, A., Lim, E. T., & Church, G. M. (2018) · Genome Medicine

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

Cited by 17

Does systemic inflammation prompt gene therapy uveitis?

Chan, Y. K., & Pepple, K. L. (2021) · Molecular Therapy

Virus-based gene therapy researchOcular Diseases and Behçet’s Syndrome

Cited by 1