Schlegel, Mark K.

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

Foster, D. J., Brown, C. R., Shaikh, S., Trapp, C., Schlegel, M. K., Qian, K., Sehgal, A., Rajeev, K. G., Jadhav, V., Manoharan, M., et al. (2018) · Molecular Therapy

RNA Interference and Gene DeliveryDNA and Nucleic Acid Chemistry

Cited by 325

Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates

Brown, C. R., Gupta, S., Qin, J., Racie, T., He, G., Lentini, S., Malone, R., Yu, M., Matsuda, S., Shulga-Morskaya, S., et al. (2020) · Nucleic Acids Research

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 285

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

Janas, M. M., Schlegel, M. K., Harbison, C. E., Yilmaz, V. O., Jiang, Y., Parmar, R., Zlatev, I., Castoreno, A., Xu, H., Shulga-Morskaya, S., et al. (2018) · Nature Communications

RNA Interference and Gene DeliveryDrug-Induced Hepatotoxicity and Protection

Cited by 279

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

Brown, K. M., Nair, J. K., Janas, M. M., Anglero-Rodriguez, Y. I., Dang, L. T. H., Peng, H., Theile, C. S., Castellanos-Rizaldos, E., Brown, C., Foster, D., et al. (2022) · Nature Biotechnology

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 258

On the Structure and Dynamics of Duplex GNA

Johnson, A. T., Schlegel, M. K., Meggers, E., Essen, L.-O., & Wiest, O. (2011) · The Journal of Organic Chemistry

DNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms

Cited by 28

An investigational RNAi therapeutic targeting factor XII (ALN-F12) for the treatment of hereditary Angioedema

Akinc, A., Liu, J., Qin, J., Castoreno, A., Schlegel, M., Maier, M., Fitzgerald, K., & Meyers, R. (2016) · Journal of Allergy and Clinical Immunology

Coagulation, Bradykinin, Polyphosphates, and AngioedemaHemophilia Treatment and Research

Cited by 5