Galetin, Aleksandra

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Margolskee, A., Darwich, A. S., Pepin, X., Aarons, L., Galetin, A., Rostami-Hodjegan, A., Carlert, S., Hammarberg, M., Hilgendorf, C., Johansson, P., et al. (2017) · European Journal of Pharmaceutical Sciences

Drug Solubulity and Delivery SystemsPharmaceutical studies and practices

Cited by 69

Identification of the Effect of Multiple Polymorphisms on the Pharmacokinetics of Simvastatin and Simvastatin Acid Using a Population-Modeling Approach

Tsamandouras, N., Dickinson, G., Guo, Y., Hall, S., Rostami-Hodjegan, A., Galetin, A., & Aarons, L. (2014) · Clinical Pharmacology & Therapeutics

Pharmacogenetics and Drug MetabolismLipoproteins and Cardiovascular Health

Cited by 68

Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach

Tsamandouras, N., Dickinson, G., Guo, Y., Hall, S., Rostami-Hodjegan, A., Galetin, A., & Aarons, L. (2015) · Pharmaceutical Research

Pharmacogenetics and Drug MetabolismPharmaceutical studies and practices

Cited by 64

Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance

Scotcher, D., Jones, C., Rostami-Hodjegan, A., & Galetin, A. (2016) · European Journal of Pharmaceutical Sciences

Drug Transport and Resistance MechanismsDrug Solubulity and Delivery Systems

Cited by 61

Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance

De Bruyn, T., Ufuk, A., Cantrill, C., Kosa, R. E., Bi, Y.-A., Niosi, M., Modi, S., Rodrigues, A. D., Tremaine, L. M., Varma, M. V. S., et al. (2018) · Drug Metabolism and Disposition

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 53

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Darwich, A. S., Margolskee, A., Pepin, X., Aarons, L., Galetin, A., Rostami-Hodjegan, A., Carlert, S., Hammarberg, M., Hilgendorf, C., Johansson, P., et al. (2017) · European Journal of Pharmaceutical Sciences

Drug Solubulity and Delivery SystemsComputational Drug Discovery Methods

Cited by 45

Incorporation of Lysosomal Sequestration in the Mechanistic Model for Prediction of Tissue Distribution of Basic Drugs

Assmus, F., Houston, J. B., & Galetin, A. (2017) · European Journal of Pharmaceutical Sciences

Computational Drug Discovery MethodsDrug Transport and Resistance Mechanisms

Cited by 36