Simeonov, Anton

Unexplored therapeutic opportunities in the human genome

Oprea, T. I., Bologa, C. G., Brunak, S., Campbell, A., Gan, G. N., Gaulton, A., Gomez, S. M., Guha, R., Hersey, A., Holmes, J., et al. (2018) · Nature Reviews Drug Discovery

Computational Drug Discovery MethodsBioinformatics and Genomic Networks

Cited by 378

Gene expression analysis identifies global gene dosage sensitivity in cancer

Fehrmann, R. S. N., Karjalainen, J. M., Krajewska, M., Westra, H.-J., Maloney, D., Simeonov, A., Pers, T. H., Hirschhorn, J. N., Jansen, R. C., Schultes, E. A., et al. (2015) · Nature Genetics

Genomic variations and chromosomal abnormalitiesGene expression and cancer classification

Cited by 347

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology

Richard, A. M., Huang, R., Waidyanatha, S., Shinn, P., Collins, B. J., Thillainadarajah, I., Grulke, C. M., Williams, A. J., Lougee, R. R., Judson, R. S., et al. (2021) · Chemical Research in Toxicology

Computational Drug Discovery MethodsEnvironmental Toxicology and Ecotoxicology

Cited by 323

Pharos: collating protein information to shed light on the druggable genome

Nguyen, D.-T., Mathias, S., Bologa, C., Brunak, S., Fernandez, N., Gaulton, A., Hersey, A., Holmes, J., Jensen, L. J., Karlsson, A., et al. (2017) · Nucleic Acids Research

Computational Drug Discovery MethodsBioinformatics and Genomic Networks

Cited by 279

The Tox21 robotic platform for the assessment of environmental chemicals – from vision to reality

Attene-Ramos, M. S., Miller, N., Huang, R., Michael, S., Itkin, M., Kavlock, R. J., Austin, C. P., Shinn, P., Simeonov, A., Tice, R. R., et al. (2013) · Drug Discovery Today

Effects and risks of endocrine disrupting chemicalsComputational Drug Discovery Methods

Cited by 255

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

Hinohara, K., Wu, H.-J., Vigneau, S., McDonald, T. O., Igarashi, K. J., Yamamoto, K. N., Madsen, T., Fassl, A., Egri, S. B., Papanastasiou, M., et al. (2018) · Cancer Cell

Epigenetics and DNA MethylationCancer Cells and Metastasis

Cited by 255

TCRD and pharos 2021: mining the human proteome for disease biology

Sheils, T. K., Mathias, S. L., Kelleher, K. J., Siramshetty, V. B., Nguyen, D.-T., Bologa, C. G., Jensen, L. J., Vidović, D., Koleti, A., Schürer, S. C., et al. (2021) · Nucleic Acids Research

Computational Drug Discovery MethodsBioinformatics and Genomic Networks

Cited by 160

Drug discovery and development for rare genetic disorders

Sun, W., Zheng, W., & Simeonov, A. (2017) · American Journal of Medical Genetics Part A

Genomics and Rare DiseasesComputational Drug Discovery Methods

Cited by 107

Robotic high-throughput biomanufacturing and functional differentiation of human pluripotent stem cells

Tristan, C. A., Ormanoglu, P., Slamecka, J., Malley, C., Chu, P.-H., Jovanovic, V. M., Gedik, Y., Jethmalani, Y., Bonney, C., Barnaeva, E., et al. (2021) · Stem Cell Reports

Pluripotent Stem Cells ResearchMesenchymal stem cell research

Cited by 80

Identification of a G-Protein-Independent Activator of GIRK Channels

Zhao, Y., Ung, P. M.-U., Zahoránszky-Kőhalmi, G., Zakharov, A. V., Martinez, N. J., Simeonov, A., Glaaser, I. W., Rai, G., Schlessinger, A., Marugan, J. J., et al. (2020) · Cell Reports

Ion channel regulation and functionNeuroscience and Neuropharmacology Research

Cited by 39

A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ

Yamanaka, K., Dorjsuren, D., Eoff, R. L., Egli, M., Maloney, D. J., Jadhav, A., Simeonov, A., & Lloyd, R. S. (2012) · PLoS ONE

DNA Repair MechanismsCancer therapeutics and mechanisms

Cited by 35

In vitro profiling of pesticides within the Tox21 10K compound library for bioactivity and potential toxicity

Ngan, D. K., Xia, M., Simeonov, A., & Huang, R. (2023) · Toxicology and Applied Pharmacology

Pesticide Exposure and ToxicityEnvironmental Toxicology and Ecotoxicology

Cited by 10