Hausch, Felix

Selective inhibitors of the FK506-binding protein 51 by induced fit

Gaali, S., Kirschner, A., Cuboni, S., Hartmann, J., Kozany, C., Balsevich, G., Namendorf, C., Fernandez-Vizarra, P., Sippel, C., Zannas, A. S., et al. (2015) · Nature Chemical Biology

Signaling Pathways in DiseaseTreatment of Major Depression

Cited by 245

The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress

Hartmann, J., Wagner, K. V., Liebl, C., Scharf, S. H., Wang, X.-D., Wolf, M., Hausch, F., Rein, T., Schmidt, U., Touma, C., et al. (2012) · Neuropharmacology

Stress Responses and CortisolNeuropeptides and Animal Physiology

Cited by 224

FKBP Ligands—Where We Are and Where to Go?

Kolos, J. M., Voll, A. M., Bauder, M., & Hausch, F. (2018) · Frontiers in Pharmacology

Signaling Pathways in DiseaseChemical Synthesis and Analysis

Cited by 158

Large FK506-binding proteins shape the pharmacology of rapamycin

März, A. M., Fabian, A.-K., Kozany, C., Bracher, A., & Hausch, F. (2013) · Molecular and Cellular Biology

PI3K/AKT/mTOR signaling in cancerSignaling Pathways in Disease

Cited by 141

Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function

Balsevich, G., Häusl, A. S., Meyer, C. W., Karamihalev, S., Feng, X., Pöhlmann, M. L., Dournes, C., Uribe-Marino, A., Santarelli, S., Labermaier, C., et al. (2017) · Nature Communications

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 134

The Many Faces of FKBP51

Hähle, A., Merz, S., Meyners, C., & Hausch, F. (2019) · Biomolecules

Signaling Pathways in DiseaseStress Responses and Cortisol

Cited by 119

Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties

Hartmann, J., Wagner, K. V., Gaali, S., Kirschner, A., Kozany, C., Ruhter, G., Dedic, N., Hausl, A. S., Hoeijmakers, L., Westerholz, S., et al. (2015) · Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Cited by 109

The prospect of FKBP51 as a drug target

Schmidt, M. V., Paez‐Pereda, M., Holsboer, F., & Hausch, F. (2012) · ChemMedChem

Stress Responses and CortisolHeat shock proteins research

Cited by 99

Fluorescent Probes to Characterise FK506‐Binding Proteins

Kozany, C., März, A., Kress, C., & Hausch, F. (2009) · ChemBioChem

Signaling Pathways in DiseasePI3K/AKT/mTOR signaling in cancer

Cited by 91

Hippocampal neuroligin-2 links early-life stress with impaired social recognition and increased aggression in adult mice

Kohl, C., Wang, X.-D., Grosse, J., Fournier, C., Harbich, D., Westerholz, S., Li, J.-T., Bacq, A., Sippel, C., Hausch, F., et al. (2015) · Psychoneuroendocrinology

Stress Responses and CortisolNeuroendocrine regulation and behavior

Cited by 76

Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52

Gopalakrishnan, R., Kozany, C., Gaali, S., Kress, C., Hoogeland, B., Bracher, A., & Hausch, F. (2012) · Journal of Medicinal Chemistry

Signaling Pathways in DiseasePI3K/AKT/mTOR signaling in cancer

Cited by 64

Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90

Bracher, A., Kozany, C., Thost, A.-K., & Hausch, F. (2011) · Acta Crystallographica Section D Biological Crystallography

Signaling Pathways in DiseaseHeat shock proteins research

Cited by 62

Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control

Wang, Y., Kirschner, A., Fabian, A.-K., Gopalakrishnan, R., Kress, C., Hoogeland, B., Koch, U., Kozany, C., Bracher, A., & Hausch, F. (2013) · Journal of Medicinal Chemistry

Signaling Pathways in DiseaseChemical Synthesis and Analysis

Cited by 60

Structure-Based Design of High-Affinity Macrocyclic FKBP51 Inhibitors

Bauder, M., Meyners, C., Purder, P. L., Merz, S., Sugiarto, W. O., Voll, A. M., Heymann, T., & Hausch, F. (2021) · Journal of Medicinal Chemistry

Signaling Pathways in DiseaseChemical Synthesis and Analysis

Cited by 53

Exploration of pipecolate sulfonamides as binders of the FK506-binding proteins 51 and 52

Gopalakrishnan, R., Kozany, C., Wang, Y., Schneider, S., Hoogeland, B., Bracher, A., & Hausch, F. (2012) · Journal of Medicinal Chemistry

Chemical Synthesis and AnalysisSignaling Pathways in Disease

Cited by 52

Crystal structures of the free and ligand-bound FK1–FK2 domain segment of FKBP52 reveal a flexible inter-domain hinge

Bracher, A., Kozany, C., Hähle, A., Wild, P., Zacharias, M., & Hausch, F. (2013) · Journal of Molecular Biology

Signaling Pathways in DiseaseHeat shock proteins research

Cited by 45

Recent Progress in FKBP Ligand Development

Feng, X., Pomplun, S., & Hausch, F. (2015) · Current Molecular Pharmacology

Signaling Pathways in DiseaseTreatment of Major Depression

Cited by 22

Large-scale, in-cell photocrosslinking at single-residue resolution reveals the molecular basis for glucocorticoid receptor regulation by immunophilins

Baischew, A., Engel, S., Taubert, M. C., Geiger, T. M., & Hausch, F. (2023) · Nature Structural & Molecular Biology

Heat shock proteins researchEstrogen and related hormone effects

Cited by 22