Webb, Andrew I.

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

Murphy, J. M., Czabotar, P. E., Hildebrand, J. M., Lucet, I. S., Zhang, J.-G., Alvarez-Diaz, S., Lewis, R., Lalaoui, N., Metcalf, D., Webb, A. I., et al. (2013) · Immunity

Cell death mechanisms and regulationNF-κB Signaling Pathways

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Linear ubiquitination prevents inflammation and regulates immune signalling

Gerlach, B., Cordier, S. M., Schmukle, A. C., Emmerich, C. H., Rieser, E., Haas, T. L., Webb, A. I., Rickard, J. A., Anderton, H., Wong, W. W.-L., et al. (2011) · Nature

NF-κB Signaling PathwaysImmune Response and Inflammation

Cited by 940

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Hildebrand, J. M., Tanzer, M. C., Lucet, I. S., Young, S. N., Spall, S. K., Sharma, P., Pierotti, C., Garnier, J.-M., Dobson, R. C. J., Webb, A. I., et al. (2014) · Proceedings of the National Academy of Sciences

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 598

VDAC2 enables BAX to mediate apoptosis and limit tumor development

Chin, H. S., Li, M. X., Tan, I. K. L., Ninnis, R. L., Reljic, B., Scicluna, K., Dagley, L. F., Sandow, J. J., Kelly, G. L., Samson, A. L., et al. (2018) · Nature Communications

Cell death mechanisms and regulationMitochondrial Function and Pathology

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Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

Hogg, S. J., Motorna, O., Cluse, L. A., Johanson, T. M., Coughlan, H. D., Raviram, R., Myers, R. M., Costacurta, M., Todorovski, I., Pijpers, L., et al. (2021) · Molecular Cell

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 170

T Cell Determinants Incorporating β-Amino Acid Residues Are Protease Resistant and Remain Immunogenic In Vivo

Webb, A. I., Dunstone, M. A., Williamson, N. A., Price, J. D., de Kauwe, A., Chen, W., Oakley, A., Perlmutter, P., McCluskey, J., Aguilar, M.-I., et al. (2005) · The Journal of Immunology

vaccines and immunoinformatics approachesImmunotherapy and Immune Responses

Cited by 57

Major histocompatibility class II in murine antigen presenting cells is modified with a branched K63 and K11-linked ubiquitin chain

Liu, H., Francis, L., Dagley, L. F., Cobbold, S. A., Webb, A. I., Komander, D., Villadangos, J. A., & Mintern, J. D. (2025) · Scientific Reports

Ubiquitin and proteasome pathwaysImmunotherapy and Immune Responses

Cited by 2

Major histocompatibility class II in murine antigen presenting cells is modified with a branched K63 and K11-linked ubiquitin chain

Liu, H., Francis, L., Dagley, L. F., Cobbold, S. A., Webb, A. I., Komander, D., Villadangos, J. A., & Mintern, J. D. (2025) · Scientific Reports

Ubiquitin and proteasome pathwaysImmunotherapy and Immune Responses

Cited by 2