Benner, Christopher

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

Zhou, Y., Zhou, B., Pache, L., Chang, M., Khodabakhshi, A. H., Tanaseichuk, O., Benner, C., & Chanda, S. K. (2019) · Nature Communications

Bioinformatics and Genomic NetworksGenomics and Phylogenetic Studies

Cited by 14,611

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 13,382

The selection and function of cell type-specific enhancers

Heinz, S., Romanoski, C. E., Benner, C., & Glass, C. K. (2015) · Nature Reviews Molecular Cell Biology

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 1,010

Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription

Kaikkonen, M. U., Spann, N. J., Heinz, S., Romanoski, C. E., Allison, K. A., Stender, J. D., Chun, H. B., Tough, D. F., Prinjha, R. K., Benner, C., et al. (2013) · Molecular Cell

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 672

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

Shalapour, S., Lin, X.-J., Bastian, I. N., Brain, J., Burt, A. D., Aksenov, A. A., Vrbanac, A. F., Li, W., Perkins, A., Matsutani, T., et al. (2017) · Nature

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 589

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

Lam, M. T. Y., Cho, H., Lesch, H. P., Gosselin, D., Heinz, S., Tanaka-Oishi, Y., Benner, C., Kaikkonen, M. U., Kim, A. S., Kosaka, M., et al. (2013) · Nature

Genomics and Chromatin DynamicsCancer-related molecular mechanisms research

Cited by 548

Transcription Elongation Can Affect Genome 3D Structure

Heinz, S., Texari, L., Hayes, M. G. B., Urbanowski, M., Chang, M. W., Givarkes, N., Rialdi, A., White, K. M., Albrecht, R. A., Pache, L., et al. (2018) · Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 453

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

Crotti, A., Benner, C., Kerman, B. E., Gosselin, D., Lagier-Tourenne, C., Zuccato, C., Cattaneo, E., Gage, F. H., Cleveland, D. W., & Glass, C. K. (2014) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsGenetic Neurodegenerative Diseases

Cited by 333

The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression

Benner, C., van der Meulen, T., Cacéres, E., Tigyi, K., Donaldson, C. J., & Huising, M. O. (2014) · BMC Genomics

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 302

Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN

Arnoult, N., Correia, A., Ma, J., Merlo, A., Garcia-Gomez, S., Maric, M., Tognetti, M., Benner, C. W., Boulton, S. J., Saghatelian, A., et al. (2017) · Nature

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 299

Effect of natural genetic variation on enhancer selection and function

Heinz, S., Romanoski, C. E., Benner, C., Allison, K. A., Kaikkonen, M. U., Orozco, L. D., & Glass, C. K. (2013) · Nature

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 298

Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate

Lin, Y. C., Benner, C., Mansson, R., Heinz, S., Miyazaki, K., Miyazaki, M., Chandra, V., Bossen, C., Glass, C. K., & Murre, C. (2012) · Nature Immunology

Genomics and Chromatin DynamicsT-cell and B-cell Immunology

Cited by 281

Identification of Novel Long Noncoding RNAs Underlying Vertebrate Cardiovascular Development

Kurian, L., Aguirre, A., Sancho-Martinez, I., Benner, C., Hishida, T., Nguyen, T. B., Reddy, P., Nivet, E., Krause, M. N., Nelles, D. A., et al. (2015) · Circulation

Cancer-related molecular mechanisms researchCongenital heart defects research

Cited by 189

Dynamic epigenetic enhancer signatures reveal key transcription factors associated with monocytic differentiation states

Pham, T.-H., Benner, C., Lichtinger, M., Schwarzfischer, L., Hu, Y., Andreesen, R., Chen, W., & Rehli, M. (2012) · Blood

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 143

Mechanisms of in vivo binding site selection of the hematopoietic master transcription factor PU.1

Pham, T.-H., Minderjahn, J., Schmidl, C., Hoffmeister, H., Schmidhofer, S., Chen, W., Längst, G., Benner, C., & Rehli, M. (2013) · Nucleic Acids Research

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 102

ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance

Ramms, B., Patel, S., Nora, C., Pessentheiner, A. R., Chang, M. W., Green, C. R., Golden, G. J., Secrest, P., Krauss, R. M., Metallo, C. M., et al. (2019) · Journal of Lipid Research

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 59

Glucocorticoid receptor-regulated enhancers play a central role in the gene regulatory networks underlying drug addiction

Duttke, S. H., Montilla-Perez, P., Chang, M. W., Li, H., Chen, H., Carrette, L. L. G., Guglielmo, G. D., George, O., Palmer, A. A., Benner, C., et al. (2022) · Frontiers in Neuroscience

Genomics and Chromatin DynamicsNeurotransmitter Receptor Influence on Behavior

Cited by 26

The Wild West of spike-in normalization

Patel, L. A., Cao, Y., Mendenhall, E. M., Benner, C., & Goren, A. (2024) · Nature Biotechnology

Genomics and Chromatin DynamicsGenomics and Phylogenetic Studies

Cited by 20