Kruhlak, Michael J.

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

Celeste, A., Fernandez-Capetillo, O., Kruhlak, M. J., Pilch, D. R., Staudt, D. W., Lee, A., Bonner, R. F., Bonner, W. M., & Nussenzweig, A. (2003) · Nature Cell Biology

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 989

T cell stemness and dysfunction in tumors are triggered by a common mechanism

Vodnala, S. K., Eil, R., Kishton, R. J., Sukumar, M., Yamamoto, T. N., Ha, N.-H., Lee, P.-H., Shin, M., Patel, S. J., Yu, Z., et al. (2019) · Science

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 552

Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

Kruhlak, M. J., Celeste, A., Dellaire, G., Fernandez-Capetillo, O., Müller, W. G., McNally, J. G., Bazett-Jones, D. P., & Nussenzweig, A. (2006) · The Journal of Cell Biology

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 518

The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks

Kruhlak, M., Crouch, E. E., Orlov, M., Montaño, C., Gorski, S. A., Nussenzweig, A., Misteli, T., Phair, R. D., & Casellas, R. (2007) · Nature

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 305

KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis

Murgai, M., Ju, W., Eason, M., Kline, J., Beury, D. W., Kaczanowska, S., Miettinen, M. M., Kruhlak, M., Lei, H., Shern, J. F., et al. (2017) · Nature Medicine

Cancer Cells and MetastasisKruppel-like factors research

Cited by 263

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

Difilippantonio, S., Celeste, A., Fernandez-Capetillo, O., Chen, H.-T., Martin, B. R. S., Laethem, F. V., Yang, Y.-P., Petukhova, G. V., Eckhaus, M., Feigenbaum, L., et al. (2005) · Nature Cell Biology

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 227

A Macrohistone Variant Links Dynamic Chromatin Compaction to BRCA1-Dependent Genome Maintenance

Khurana, S., Kruhlak, M. J., Kim, J., Tran, A. D., Liu, J., Nyswaner, K., Shi, L., Jailwala, P., Sung, M.-H., Hakim, O., et al. (2014) · Cell Reports

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 220

Activation of DNA Damage Response Signaling by Condensed Chromatin

Burgess, R. C., Burman, B., Kruhlak, M. J., & Misteli, T. (2014) · Cell Reports

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 198

Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis

Langer, H. F., Chung, K.-J., Orlova, V. V., Choi, E. Y., Kaul, S., Kruhlak, M. J., Alatsatianos, M., DeAngelis, R. A., Roche, P. A., Magotti, P., et al. (2010) · Blood

Complement system in diseasesAngiogenesis and VEGF in Cancer

Cited by 176

Phospholipase C–mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane

Hao, J.-J., Liu, Y., Kruhlak, M., Debell, K. E., Rellahan, B. L., & Shaw, S. (2009) · Journal of Cell Biology

Protein Kinase Regulation and GTPase SignalingCellular Mechanics and Interactions

Cited by 137

Active DNA demethylation promotes cell fate specification and the DNA damage response

Wang, D., Wu, W., Callen, E., Pavani, R., Zolnerowich, N., Kodali, S., Zong, D., Wong, N., Noriega, S., Nathan, W. J., et al. (2022) · Science

DNA Repair MechanismsEpigenetics and DNA Methylation

Cited by 113