Lightfoot, Howard

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

Yang, W., Soares, J., Greninger, P., Edelman, E. J., Lightfoot, H., Forbes, S., Bindal, N., Beare, D., Smith, J. A., Thompson, I. R., et al. (2012) · Nucleic Acids Research

Cancer Genomics and DiagnosticsComputational Drug Discovery Methods

Cited by 4,051

A Landscape of Pharmacogenomic Interactions in Cancer

Iorio, F., Knijnenburg, T. A., Vis, D. J., Bignell, G. R., Menden, M. P., Schubert, M., Aben, N., Gonçalves, E., Barthorpe, S., Lightfoot, H., et al. (2016) · Cell

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 2,090

Effective drug combinations in breast, colon and pancreatic cancer cells

Jaaks, P., Coker, E. A., Vis, D. J., Edwards, O., Carpenter, E. F., Leto, S. M., Dwane, L., Sassi, F., Lightfoot, H., Barthorpe, S., et al. (2022) · Nature

Computational Drug Discovery MethodsCancer Genomics and Diagnostics

Cited by 469

Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics

Li, X., Francies, H. E., Secrier, M., Perner, J., Miremadi, A., Galeano-Dalmau, N., Barendt, W. J., Letchford, L., Leyden, G. M., Goffin, E. K., et al. (2018) · Nature Communications

Esophageal Cancer Research and TreatmentCancer Cells and Metastasis

Cited by 316

Cell Model Passports-a hub for clinical, genetic and functional datasets of preclinical cancer models

van der Meer, D., Barthorpe, S., Yang, W., Lightfoot, H., Hall, C., Gilbert, J., Francies, H. E., & Garnett, M. J. (2019) · Nucleic Acids Research

Cancer Genomics and DiagnosticsCancer Cells and Metastasis

Cited by 195

Multilevel models Improve precision and Speed of IC 50 Estimates

Vis, D. J., Bombardelli, L., Lightfoot, H., Iorio, F., Garnett, M. J., & Wessels, L. F. (2016) · Pharmacogenomics

Computational Drug Discovery MethodsStatistical Methods and Bayesian Inference

Cited by 71