Tybulewicz, Victor L. J.

The SYK tyrosine kinase: A crucial player in diverse biological functions

Mócsai, A., Ruland, J., & Tybulewicz, V. L. J. (2010) · Nature Reviews Immunology

Immune Response and InflammationNF-κB Signaling Pathways

Cited by 1,368

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

LeibundGut-Landmann, S., Groß, O., Robinson, M. J., Osorio, F., Slack, E. C., Tsoni, S. V., Schweighoffer, E., Tybulewicz, V., Brown, G. D., Ruland, J., et al. (2007) · Nature Immunology

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 1,191

Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II

Liang, B., Workman, C., Lee, J., Chew, C., Dale, B. M., Colonna, L., Flores, M., Li, N., Schweighoffer, E., Greenberg, S., et al. (2008) · The Journal of Immunology

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 566

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

Wiseman, F. K., Al-Janabi, T., Hardy, J., Karmiloff-Smith, A., Nizetic, D., Tybulewicz, V. L. J., Fisher, E. M. C., & Strydom, A. (2015) · Nature Reviews Neuroscience

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 562

A critical role for Syk in signal transduction and phagocytosis mediated by Fcγ receptors on macrophages

Crowley, M. T., Costello, P. S., Fitzer-Attas, C. J., Turner, M., Meng, F., Lowell, C., Tybulewicz, V. L. J., & DeFranco, A. L. (1997) · The Journal of Experimental Medicine

Phagocytosis and Immune RegulationMonoclonal and Polyclonal Antibodies Research

Cited by 506

An Aneuploid Mouse Strain Carrying Human Chromosome 21 with down Syndrome Phenotypes.

O'Doherty, A., Ruf, S., Mulligan, C., Hildreth, V., Errington, M. L., Cooke, S., Sesay, A., Modino, S., Vanes, L., Hernandez, D., et al. (2005) · Science

Down syndrome and intellectual disability researchGenomic variations and chromosomal abnormalities

Cited by 434

Syk is required for integrin signaling in neutrophils

Mócsai, A., Zhou, M., Meng, F., Tybulewicz, V. L., & Lowell, C. A. (2002) · Immunity

Cell Adhesion Molecules ResearchNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 421

Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years

Hithersay, R., Startin, C. M., Hamburg, S., Mok, K. Y., Hardy, J., Fisher, E. M. C., Tybulewicz, V. L. J., Nizetic, D., & Strydom, A. (2019) · JAMA Neurology

Down syndrome and intellectual disability researchDementia and Cognitive Impairment Research

Cited by 176

Activation of the Small GTPase Rac2 via the B Cell Receptor Regulates B Cell Adhesion and Immunological-Synapse Formation

Arana, E., Vehlow, A., Harwood, N. E., Vigorito, E., Henderson, R., Turner, M., Tybulewicz, V. L. J., & Batista, F. D. (2008) · Immunity

Protein Kinase Regulation and GTPase SignalingCell Adhesion Molecules Research

Cited by 156

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

Alić, I., Goh, P. A., Murray, A., Portelius, E., Gkanatsiou, E., Gough, G., Mok, K. Y., Koschut, D., Brunmeir, R., Yeap, Y. J., et al. (2021) · Molecular Psychiatry

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 123

Massively Parallel Sequencing Reveals the Complex Structure of an Irradiated Human Chromosome on a Mouse Background in the Tc1 Model of down Syndrome.

Gribble, S. M., Wiseman, F. K., Clayton, S., Prigmore, E., Langley, E., Yang, F., Maguire, S., Fu, B., Rajan, D., Sheppard, O., et al. (2013) · PLoS ONE

Down syndrome and intellectual disability researchGenomic variations and chromosomal abnormalities

Cited by 102

Inhibition of β2 Integrin Receptor and Syk Kinase Signaling in Monocytes by the Src Family Kinase Fgr

Vines, C. M., Potter, J. W., Xu, Y., Geahlen, R. L., Costello, P. S., Tybulewicz, V. L., Lowell, C. A., Chang, P. W., Gresham, H. D., & Willman, C. L. (2001) · Immunity

Cell Adhesion Molecules ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 87

Alterations to Dendritic Spine Morphology, but Not Dendrite Patterning, of Cortical Projection Neurons in Tc1 and Ts1Rhr Mouse Models of Down Syndrome

Haas, M. A., Bell, D., Slender, A., Lana-Elola, E., Watson-Scales, S., Fisher, E. M. C., Tybulewicz, V. L. J., & Guillemot, F. (2013) · PLoS ONE

Down syndrome and intellectual disability researchGenetics and Neurodevelopmental Disorders

Cited by 48

Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift

Zhang, Y., Garcia-Ibanez, L., Ulbricht, C., Lok, L. S. C., Pike, J. A., Mueller-Winkler, J., Dennison, T. W., Ferdinand, J. R., Burnett, C. J. M., Yam-Puc, J. C., et al. (2022) · Nature Communications

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 47

Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome

Chang, P., Bush, D., Schorge, S., Good, M., Canonica, T., Shing, N., Noy, S., Wiseman, F. K., Burgess, N., Tybulewicz, V. L. J., et al. (2020) · Cell Reports

Down syndrome and intellectual disability researchGenetics and Neurodevelopmental Disorders

Cited by 47

Analysis of motor dysfunction in down Syndrome reveals motor neuron degeneration.

Watson-Scales, S., Kalmar, B., Lana-Elola, E., Gibbins, D., La Russa, F., Wiseman, F., Williamson, M., Saccon, R., Slender, A., Olerinyova, A., et al. (2018) · PLOS Genetics

Down syndrome and intellectual disability researchGenetics and Neurodevelopmental Disorders

Cited by 45

Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of down syndrome-related phenotypes.

Lana-Elola, E., Cater, H., Watson-Scales, S., Greenaway, S., Müller-Winkler, J., Gibbins, D., Nemes, M., Slender, A., Hough, T., Keskivali-Bond, P., et al. (2021) · Disease Models & Mechanisms

Down syndrome and intellectual disability researchWilliams Syndrome Research

Cited by 35

Mouse models of aneuploidy to understand chromosome disorders

Tosh, J., Tybulewicz, V., & Fisher, E. M. C. (2022) · Mammalian Genome

Down syndrome and intellectual disability researchGenomic variations and chromosomal abnormalities

Cited by 24

Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21

Mumford, P., Tosh, J., Anderle, S., Gkanatsiou Wikberg, E., Lau, G., Noy, S., Cleverley, K., Saito, T., Saido, T. C., Yu, E., et al. (2022) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 22