Siminovitch, Katherine A.

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Cordell, H. J., Han, Y., Mells, G. F., Li, Y., Hirschfield, G. M., Greene, C. S., Xie, G., Juran, B. D., Zhu, D., Qian, D. C., et al. (2015) · Nature Communications

Liver Diseases and ImmunityGenetic Associations and Epidemiology

Cited by 287

A Role for Noncoding Variation in Schizophrenia

Roussos, P., Mitchell, A. C., Voloudakis, G., Fullard, J. F., Pothula, V. M., Tsang, J., Stahl, E. A., Georgakopoulos, A., Ruderfer, D. M., Charney, A., et al. (2014) · Cell Reports

Genetic Associations and EpidemiologySchizophrenia research and treatment

Cited by 251

Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice.

Kozlowski, M., Mlinaric-Rascan, I., Feng, G. S., Shen, R., Pawson, T., & Siminovitch, K. A. (1993) · The Journal of experimental medicine

Protein Tyrosine PhosphatasesImmunodeficiency and Autoimmune Disorders

Cited by 235

Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis

Hirschfield, G. M., Liu, X., Han, Y., Gorlov, I. P., Lu, Y., Xu, C., Lu, Y., Chen, W., Juran, B. D., Coltescu, C., et al. (2010) · Nature Genetics

Liver Diseases and ImmunityGenetic Associations and Epidemiology

Cited by 215

Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation

Leng, Y., Zhang, J., Badour, K., Arpaia, E., Freeman, S., Cheung, P., Siu, M., & Siminovitch, K. (2005) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingCellular Mechanics and Interactions

Cited by 210

Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants

Juran, B. D., Hirschfield, G. M., Invernizzi, P., Atkinson, E. J., Li, Y., Xie, G., Kosoy, R., Ransom, M., Sun, Y., Bianchi, I., et al. (2012) · Human Molecular Genetics

Liver Diseases and ImmunityGenetic Associations and Epidemiology

Cited by 150

Negative Regulation of Myeloid Cell Proliferation and Function by the SH2 Domain-Containing Tyrosine Phosphatase-1

Dong, Q., Siminovitch, K. A., Fialkow, L., Fukushima, T., & Downey, G. P. (1999) · The Journal of Immunology

Protein Tyrosine PhosphatasesCytokine Signaling Pathways and Interactions

Cited by 58

X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis

Asselta, R., Paraboschi, E. M., Gerussi, A., Cordell, H. J., Mells, G. F., Sandford, R. N., Jones, D. E., Nakamura, M., Ueno, K., Hitomi, Y., et al. (2021) · Gastroenterology

Liver Diseases and ImmunityGenetic Associations and Epidemiology

Cited by 55

WAVE2 suppresses mTOR activation to maintain T cell homeostasis and prevent autoimmunity

Liu, M., Zhang, J., Pinder, B. D., Liu, Q., Wang, D., Yao, H., Gao, Y., Toker, A., Gao, J., Peterson, A., et al. (2021) · Science

T-cell and B-cell ImmunologyPI3K/AKT/mTOR signaling in cancer

Cited by 53

Exploration of the genetic architecture of ANCA-associated vasculitis

Byun, J., Shaw, V. R., Zhu, C., Han, Y., Sun, R., Zhang, Z., Xiao, X., Pinder, B. D., Zhang, J., Tadesse, Y., et al. (2026) · eBioMedicine

Vasculitis and related conditionsGenetic Associations and Epidemiology

Cited by 0