Timpson, Paul

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

Morton, J. P., Timpson, P., Karim, S. A., Ridgway, R. A., Athineos, D., Doyle, B., Jamieson, N. B., Oien, K. A., Lowy, A. M., Brunton, V. G., et al. (2010) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysPancreatic and Hepatic Oncology Research

Cited by 657

Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer

Cazet, A. S., Hui, M. N., Elsworth, B. L., Wu, S. Z., Roden, D., Chan, C.-L., Skhinas, J. N., Collot, R., Yang, J., Harvey, K., et al. (2018) · Nature Communications

Hedgehog Signaling Pathway StudiesCancer Cells and Metastasis

Cited by 437

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

McDonald, M. M., Khoo, W. H., Ng, P. Y., Xiao, Y., Zamerli, J., Thatcher, P., Kyaw, W., Pathmanandavel, K., Grootveld, A. K., Moran, I., et al. (2021) · Cell

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 433

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Vennin, C., Mélénec, P., Rouet, R., Nobis, M., Cazet, A. S., Murphy, K. J., Herrmann, D., Reed, D. A., Lucas, M. C., Warren, S. C., et al. (2019) · Nature Communications

Pancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis

Cited by 268

Nuclear F-Actin Counteracts Nuclear Deformation and Promotes Fork Repair during Replication Stress

Lamm, N., Read, M. N., Nobis, M., Van Ly, D., Page, S. G., Masamsetti, V. P., Timpson, P., Biro, M., & Cesare, A. J. (2020) · Nature Cell Biology

DNA Repair MechanismsMicrotubule and mitosis dynamics

Cited by 156

Dasatinib Inhibits the Development of Metastases in a Mouse Model of Pancreatic Ductal Adenocarcinoma

Morton, J. P., Karim, S. A., Graham, K., Timpson, P., Jamieson, N., Athineos, D., Doyle, B., McKay, C., Heung, M., Oien, K. A., et al. (2010) · Gastroenterology

Pancreatic and Hepatic Oncology ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 148

MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer

Cipponi, A., Goode, D. L., Bedo, J., McCabe, M. J., Pajic, M., Croucher, D. R., Rajal, A. G., Junankar, S. R., Saunders, D. N., Lobachevsky, P., et al. (2020) · Science

PI3K/AKT/mTOR signaling in cancerEvolution and Genetic Dynamics

Cited by 103

MASTL overexpression promotes chromosome instability and metastasis in breast cancer

Rogers, S., McCloy, R. A., Parker, B. L., Gallego-Ortega, D., Law, A. M. K., Chin, V. T., Conway, J. R. W., Fey, D., Millar, E. K. A., O’Toole, S., et al. (2018) · Oncogene

Microtubule and mitosis dynamicsCancer-related Molecular Pathways

Cited by 67

Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells

Dawson, J. C., Timpson, P., Kalna, G., & Machesky, L. M. (2012) · Oncogene

HER2/EGFR in Cancer ResearchHead and Neck Cancer Studies

Cited by 42

Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC

Boslem, E., Reibe, S., Carlessi, R., Smeuninx, B., Tegegne, S., Egan, C. L., McLennan, E., Terry, L. V., Nobis, M., Mu, A., et al. (2023) · Science Advances

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 39