Gate, David

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

Gate, D., Saligrama, N., Leventhal, O., Yang, A. C., Unger, M. S., Middeldorp, J., Chen, K., Lehallier, B., Channappa, D., De Los Santos, M. B., et al. (2020) · Nature

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 992

Undulating changes in human plasma proteome profiles across the lifespan

Lehallier, B., Gate, D., Schaum, N., Nanasi, T., Lee, S. E., Yousef, H., Moran Losada, P., Berdnik, D., Keller, A., Verghese, J., et al. (2019) · Nature Medicine

Genetics, Aging, and Longevity in Model OrganismsAdvanced Proteomics Techniques and Applications

Cited by 981

A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk

Yang, A. C., Vest, R. T., Kern, F., Lee, D. P., Agam, M., Maat, C. A., Losada, P. M., Chen, M. B., Schaum, N., Khoury, N., et al. (2022) · Nature

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 797

Dysregulation of brain and choroid plexus cell types in severe COVID-19

Yang, A. C., Kern, F., Losada, P. M., Agam, M. R., Maat, C. A., Schmartz, G. P., Fehlmann, T., Stein, J. A., Schaum, N., Lee, D. P., et al. (2021) · Nature

Long-Term Effects of COVID-19Single-cell and spatial transcriptomics

Cited by 620

Physiological blood–brain transport is impaired with age by a shift in transcytosis

Yang, A. C., Stevens, M. Y., Chen, M. B., Lee, D. P., Stähli, D., Gate, D., Contrepois, K., Chen, W., Iram, T., Zhang, L., et al. (2020) · Nature

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 477

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

Pluvinage, J. V., Haney, M. S., Smith, B. A. H., Sun, J., Iram, T., Bonanno, L., Li, L., Lee, D. P., Morgens, D. W., Yang, A. C., et al. (2019) · Nature

Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

Cited by 459

Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology

Guillot-Sestier, M.-V., Doty, K. R., Gate, D., Rodriguez, J., Leung, B. P., Rezai-Zadeh, K., & Town, T. (2015) · Neuron

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 363

Deciphering spatial domains from spatial multi-omics with SpatialGlue

Long, Y., Ang, K. S., Sethi, R., Liao, S., Heng, Y., van Olst, L., Ye, S., Zhong, C., Xu, H., Zhang, D., et al. (2024) · Nature Methods

Single-cell and spatial transcriptomicsBioinformatics and Genomic Networks

Cited by 223

Macrophages in Alzheimer’s disease: the blood-borne identity

Gate, D., Rezai-Zadeh, K., Jodry, D., Rentsendorj, A., & Town, T. (2010) · Journal of Neural Transmission

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 107

A human brain vascular atlas reveals diverse cell mediators of Alzheimer’s disease risk

Yang, A. C., Vest, R. T., Kern, F., Lee, D. P., Maat, C. A., Losada, P. M., Chen, M. B., Agam, M., Schaum, N., Khoury, N., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory)

Barrier Structure and Function StudiesSingle-cell and spatial transcriptomics

Cited by 48

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference

Kloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., Carrillo, M. C., Chen, X., Chiba‐Falek, O., Davis, A. A., Paolo, G. D., Garretti, F., et al. (2024) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 33