Ratcliffe, Peter J.

Mechanisms of hypoxia signalling: new implications for nephrology

Schödel, J., & Ratcliffe, P. J. (2019) · Nature Reviews Nephrology

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 309

Oxygen sensing and hypoxia signalling pathways in animals: The implications of physiology for cancer

Ratcliffe, P. J. (2013) · The Journal of Physiology

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 294

Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

Cockman, M. E., Lancaster, D. E., Stolze, I. P., Hewitson, K. S., McDonough, M. A., Coleman, M. L., Coles, C. H., Yu, X., Hay, R. T., Ley, S. C., et al. (2006) · Proceedings of the National Academy of Sciences

NF-κB Signaling PathwaysCancer, Hypoxia, and Metabolism

Cited by 285

Aberrant succination of proteins in fumarate hydratase‐deficient mice and HLRCC patients is a robust biomarker of mutation status

Bardella, C., El‐Bahrawy, M., Frizzell, N., Adam, J., Ternette, N., Hatipoglu, E., Howarth, K., O'Flaherty, L., Roberts, I., Turner, G., et al. (2011) · The Journal of Pathology

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 281

Oxygen-regulated and Transactivating Domains in Endothelial PAS Protein 1: Comparison with Hypoxia-inducible Factor-1α

O'Rourke, J. F., Tian, Y.-M., Ratcliffe, P. J., & Pugh, C. W. (1999) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismKruppel-like factors research

Cited by 242

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

Ehrismann, D., Flashman, E., Genn, D. N., Mathioudakis, N., Hewitson, K. S., Ratcliffe, P. J., & Schofield, C. J. (2007) · Biochemical Journal

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 225

Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor

Coleman, M. L., McDonough, M. A., Hewitson, K. S., Coles, C., Mecinovicí, J., Edelmann, M., Cook, K. M., Cockman, M. E., Lancaster, D. E., Kessler, B. M., et al. (2007) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 222

Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin

Smythies, J. A., Sun, M., Masson, N., Salama, R., Simpson, P. D., Murray, E., Neumann, V., Cockman, M. E., Choudhry, H., Ratcliffe, P. J., et al. (2019) · The EMBO Reports

Cancer, Hypoxia, and MetabolismGenomics and Chromatin Dynamics

Cited by 195

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

Walmsley, S. R., Chilvers, E. R., Thompson, A. A., Vaughan, K., Marriott, H. M., Parker, L. C., Shaw, G., Parmar, S., Schneider, M., Sabroe, I., et al. (2011) · Journal of Clinical Investigation

Cell death mechanisms and regulationNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 191

Mutation of von Hippel–Lindau Tumour Suppressor and Human Cardiopulmonary Physiology

Smith, T. G., Brooks, J. T., Balanos, G. M., Lappin, T. R., Layton, D. M., Leedham, D. L., Liu, C., Maxwell, P. H., McMullin, M. F., McNamara, C. J., et al. (2006) · PLoS Medicine

High Altitude and HypoxiaPulmonary Hypertension Research and Treatments

Cited by 182

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

Ge, W., Wolf, A., Feng, T., Ho, C.-H., Sekirnik, R., Zayer, A., Granatino, N., Cockman, M. E., Loenarz, C., Loik, N. D., et al. (2012) · Nature Chemical Biology

RNA and protein synthesis mechanismsRNA modifications and cancer

Cited by 154

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases

Chowdhury, R., Leung, I. K. H., Tian, Y.-M., Abboud, M. I., Ge, W., Domene, C., Cantrelle, F.-X., Landrieu, I., Hardy, A. P., Pugh, C. W., et al. (2016) · Nature Communications

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 145

2-Oxoglutarate analogue inhibitors of hif prolyl hydroxylase

Mole, D. R., Schlemminger, I., McNeill, L. A., Hewitson, K. S., Pugh, C. W., Ratcliffe, P. J., & Schofield, C. J. (2003) · Bioorganic & Medicinal Chemistry Letters

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 145

The use of dioxygen by HIF prolyl hydroxylase (PHD1)

McNeill, L. A., Hewitson, K. S., Gleadle, J. M., Horsfall, L. E., Oldham, N. J., Maxwell, P. H., Pugh, C. W., Ratcliffe, P. J., & Schofield, C. J. (2002) · Bioorganic & Medicinal Chemistry Letters

Metal-Catalyzed Oxygenation MechanismsCancer, Hypoxia, and Metabolism

Cited by 116

Target gene selectivity of hypoxia-inducible factor-α in renal cancer cells is conveyed by post-DNA-binding mechanisms

Lau, K. W., Tian, Y.-M., Raval, R. R., Ratcliffe, P. J., & Pugh, C. W. (2007) · British Journal of Cancer

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 104

A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia

Adam, J., Yang, M., Bauerschmidt, C., Kitagawa, M., O’Flaherty, L., Maheswaran, P., Özkan, G., Sahgal, N., Baban, D., Kato, K., et al. (2013) · Cell Reports

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 97

Regulation of growth differentiation factor 15 expression by intracellular iron

Lakhal, S., Talbot, N. P., Crosby, A., Stoepker, C., Townsend, A. R. M., Robbins, P. A., Pugh, C. W., Ratcliffe, P. J., & Mole, D. R. (2009) · Blood

GDF15 and Related BiomarkersIron Metabolism and Disorders

Cited by 95

Normoxic stabilization of hypoxia-inducible factor-1α by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1

Knowles, H. J., Mole, D. R., Ratcliffe, P. J., & Harris, A. L. (2006) · Cancer Research

Cancer, Hypoxia, and MetabolismIron Metabolism and Disorders

Cited by 94

Cardiopulmonary function in two human disorders of the hypoxia‐inducible factor (HIF) pathway: von Hippel‐Lindau disease and HIF‐2α gain‐of‐function mutation

Formenti, F., Beer, P. A., Croft, Q. P. P., Dorrington, K. L., Gale, D. P., Lappin, T. R. J., Lucas, G. S., Maher, E. R., Maxwell, P. H., McMullin, M. F., et al. (2011) · The FASEB Journal

Cancer, Hypoxia, and MetabolismPulmonary Hypertension Research and Treatments

Cited by 92

Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control

Cheng, X., Prange-Barczynska, M., Fielding, J. W., Zhang, M., Burrell, A. L., Lima, J. D. C. C., Eckardt, L., Argles, I. L. A., Pugh, C. W., Buckler, K. J., et al. (2020) · Journal of Clinical Investigation

Neuroscience of respiration and sleepCancer, Hypoxia, and Metabolism

Cited by 62