Wray, Naomi R.

GWAS on family history of Alzheimer’s disease

Marioni, R. E., Harris, S. E., Zhang, Q., McRae, A. F., Hagenaars, S. P., Hill, W. D., Davies, G., Ritchie, C. W., Gale, C. R., Starr, J. M., et al. (2018) · Translational Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 564

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

van Rheenen, W., van der Spek, R. A. A., Bakker, M. K., van Vugt, J. J. F. A., Hop, P. J., Zwamborn, R. A. J., de Klein, N., Westra, H.-J., Bakker, O. B., Deelen, P., et al. (2021) · Nature Genetics

Amyotrophic Lateral Sclerosis ResearchGenetic Associations and Epidemiology

Cited by 542

The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications

Moylan, S., Maes, M., Wray, N. R., & Berk, M. (2013) · Molecular Psychiatry

Treatment of Major DepressionTryptophan and brain disorders

Cited by 529

Improved polygenic prediction by Bayesian multiple regression on summary statistics

Lloyd-Jones, L. R., Zeng, J., Sidorenko, J., Yengo, L., Moser, G., Kemper, K. E., Wang, H., Zheng, Z., Magi, R., Esko, T., et al. (2019) · Nature Communications

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

Cited by 528

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

Min, J. L., Hemani, G., Hannon, E., Dekkers, K. F., Castillo-Fernandez, J., Luijk, R., Carnero-Montoro, E., Lawson, D. J., Burrows, K., Suderman, M., et al. (2021) · Nature Genetics

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 506

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Zhang, Q., Vallerga, C. L., Walker, R. M., Lin, T., Henders, A. K., Montgomery, G. W., He, J., Fan, D., Fowdar, J., Kennedy, M., et al. (2019) · Genome Medicine

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 487

Lifetime stress accelerates epigenetic aging in an urban, African American cohort: Relevance of glucocorticoid signaling

Zannas, A. S., Arloth, J., Carrillo-Roa, T., Iurato, S., Röh, S., Ressler, K. J., Nemeroff, C. B., Smith, A. K., Bradley, B., Heim, C., et al. (2015) · Genome Biology

Epigenetics and DNA MethylationStress Responses and Cortisol

Cited by 469

Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis

Schizophrenia Working Group of the Psychiatric Genomics Consortium, Loh, P.-R., Bhatia, G., Gusev, A., Finucane, H. K., Bulik-Sullivan, B. K., Pollack, S. J., de Candia, T. R., Lee, S. H., Wray, N. R., et al. (2015) · Nature Genetics

Genetic Associations and EpidemiologySchizophrenia research and treatment

Cited by 449

Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned

Wray, N. R., Pergadia, M. L., Blackwood, D. H. R., Penninx, B. W. J. H., Gordon, S. D., Nyholt, D. R., Ripke, S., MacIntyre, D. J., McGhee, K. A., Maclean, A. W., et al. (2012) · Molecular Psychiatry

Genetic Associations and EpidemiologyTreatment of Major Depression

Cited by 444

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

Qi, T., Wu, Y., Zeng, J., Zhang, F., Xue, A., Jiang, L., Zhu, Z., Kemper, K., Yengo, L., Zheng, Z., et al. (2018) · Nature Communications

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 427

A DNA methylation biomarker of alcohol consumption

Liu, C., Marioni, R. E., Hedman, Å. K., Pfeiffer, L., Tsai, P.-C., Reynolds, L. M., Just, A. C., Duan, Q., Boer, C. G., Tanaka, T., et al. (2018) · Molecular Psychiatry

Epigenetics and DNA MethylationAlcohol Consumption and Health Effects

Cited by 402

Signatures of negative selection in the genetic architecture of human complex traits

Zeng, J., de Vlaming, R., Wu, Y., Robinson, M. R., Lloyd-Jones, L. R., Yengo, L., Yap, C. X., Xue, A., Sidorenko, J., McRae, A. F., et al. (2018) · Nature Genetics

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

Cited by 391

From Basic Science to Clinical Application of Polygenic Risk Scores: A Primer

Wray, N. R., Lin, T., Austin, J., McGrath, J. J., Hickie, I. B., Murray, G. K., & Visscher, P. M. (2021) · JAMA Psychiatry

Genetic Associations and EpidemiologyGenomics and Rare Diseases

Cited by 367

Large-scale genomics unveils the genetic architecture of psychiatric disorders

Gratten, J., Wray, N. R., Keller, M. C., & Visscher, P. M. (2014) · Nature Neuroscience

Genetic Associations and EpidemiologySchizophrenia research and treatment

Cited by 363

The genetic interpretation of area under the ROC curve in genomic profiling

Wray, N. R., Yang, J., Goddard, M. E., & Visscher, P. M. (2010) · PLoS Genetics

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

Cited by 334

Polygenic Risk Score, Parental Socioeconomic Status, Family History of Psychiatric Disorders, and the Risk for Schizophrenia: A Danish Population-Based Study and Meta-analysis

Agerbo, E., Sullivan, P. F., Vilhjálmsson, B. J., Pedersen, C. B., Mors, O., Børglum, A. D., Hougaard, D. M., Hollegaard, M. V., Meier, S., Mattheisen, M., et al. (2015) · JAMA Psychiatry

Schizophrenia research and treatmentGenetic Associations and Epidemiology

Cited by 319

RICOPILI: Rapid Imputation for COnsortias PIpeLIne

Lam, M., Awasthi, S., Watson, H. J., Goldstein, J., Panagiotaropoulou, G., Trubetskoy, V., Karlsson, R., Frei, O., Fan, C.-C., De Witte, W., et al. (2020) · Bioinformatics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 315

Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk

Evans, D. M., Visscher, P. M., & Wray, N. R. (2009) · Human Molecular Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 297

A direct test of the diathesis-stress model for depression

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Colodro-Conde, L., Couvy-Duchesne, B., Zhu, G., Coventry, W. L., Byrne, E. M., Gordon, S., Wright, M. J., Montgomery, G. W., Madden, P. A. F., et al. (2018) · Molecular Psychiatry

Genetic Associations and EpidemiologyNeurotransmitter Receptor Influence on Behavior

Cited by 285

Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture

Zhang, Q., Sidorenko, J., Couvy-Duchesne, B., Marioni, R. E., Wright, M. J., Goate, A. M., Marcora, E., Huang, K.-L., Porter, T., Laws, S. M., et al. (2020) · Nature Communications

Alzheimer's disease research and treatmentsGenetic Associations and Epidemiology

Cited by 272

GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores

Mullins, N., Bigdeli, T. B., Børglum, A. D., Coleman, J. R. I., Demontis, D., Mehta, D., Power, R. A., Ripke, S., Stahl, E. A., Starnawska, A., et al. (2019) · American Journal of Psychiatry

Suicide and Self-Harm StudiesGenetic Associations and Epidemiology

Cited by 270

Genetic correlates of social stratification in Great Britain

Abdellaoui, A., Hugh-Jones, D., Yengo, L., Kemper, K. E., Nivard, M. G., Veul, L., Holtz, Y., Zietsch, B. P., Frayling, T. M., Wray, N. R., et al. (2019) · Nature Human Behaviour

Genetic Associations and EpidemiologyForensic and Genetic Research

Cited by 261

Genome-wide association study of medication-use and associated disease in the UK Biobank

Wu, Y., Byrne, E. M., Zheng, Z., Kemper, K. E., Yengo, L., Mallett, A. J., Yang, J., Visscher, P. M., & Wray, N. R. (2019) · Nature Communications

Genetic Associations and EpidemiologyPharmacogenetics and Drug Metabolism

Cited by 243

Genetic association of major depression with atypical features and obesity-related immunometabolic dysregulations

Milaneschi, Y., Lamers, F., Peyrot, W. J., Baune, B. T., Breen, G., Dehghan, A., Forstner, A. J., Grabe, H. J., Homuth, G., Kan, C., et al. (2017) · JAMA Psychiatry

Genetic Associations and EpidemiologyTryptophan and brain disorders

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