Kivirikko, Kari I.

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

Hirsilä, M., Koivunen, P., Günzler, V., Kivirikko, K. I., & Myllyharju, J. (2003) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 794

Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates

Koivunen, P., Hirsilä, M., Remes, A. M., Hassinen, I. E., Kivirikko, K. I., & Myllyharju, J. (2007) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 521

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

Koivunen, P., Hirsilä, M., Günzler, V., Kivirikko, K. I., & Myllyharju, J. (2004) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 447

Protein hydroxylation: Prolyl 4-hydroxylase, an enzyme with four cosubstrates and a multifunctional subunit

Kivirikko, K. I., Myllylä, R., & Pihlajaniemi, T. (1989) · The FASEB Journal

Metal-Catalyzed Oxygenation MechanismsCollagen: Extraction and Characterization

Cited by 320

Mechanism of the Prolyl Hydroxylase Reaction: 2. Kinetic Analysis of the Reaction Sequence

MYLLYLÄ, R., TUDERMAN, L., & KIVIRIKKO, K. I. (1977) · European Journal of Biochemistry

Metal-Catalyzed Oxygenation MechanismsProtease and Inhibitor Mechanisms

Cited by 263

Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

Heikkilä, M., Pasanen, A., Kivirikko, K. I., & Myllyharju, J. (2011) · Cellular and Molecular Life Sciences

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 213

The role of ascorbate in the prolyl hydroxylase reaction

Myllylä, R., Kuutti-Savolainen, E.-R., & Kivirikko, K. I. (1978) · Biochemical and Biophysical Research Communications

Metal-Catalyzed Oxygenation MechanismsVitamin C and Antioxidants Research

Cited by 213

Prolyl 4-hydroxylase and its role in collagen synthesis

Pihlajaniemi, T., Myllylä, R., & Kivirikko, K. I. (1991) · Journal of Hepatology

Collagen: Extraction and CharacterizationLiver physiology and pathology

Cited by 179

The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases

Koivunen, P., Hirsilä, M., Kivirikko, K. I., & Myllyharju, J. (2006) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 129

A Large Duplication in the Gene for Lysyl Hydroxylase Accounts for the Type VI Variant of Ehlers-Danlos Syndrome in Two Siblings

Hautala, T., Heikkinen, J., Kivirikko, K. I., & Myllylä, R. (1993) · Genomics

Connective tissue disorders researchSkin and Cellular Biology Research

Cited by 80

Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis

Laitala, A., Aro, E., Walkinshaw, G., Mäki, J. M., Rossi, M., Heikkilä, M., Savolainen, E.-R., Arend, M., Kivirikko, K. I., Koivunen, P., et al. (2012) · Blood

Erythropoietin and Anemia TreatmentIron Metabolism and Disorders

Cited by 58