Isaya, Grazia

Iron-Dependent Self-Assembly of Recombinant Yeast Frataxin: Implications for Friedreich Ataxia

Adamec, J., Rusnak, F., Owen, W. G., Naylor, S., Benson, L. M., Gacy, A. M., & Isaya, G. (2000) · The American Journal of Human Genetics

Mitochondrial Function and PathologyGenetic Neurodegenerative Diseases

Cited by 255

Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity

Gakh, O., Park, S., Liu, G., Macomber, L., Imlay, J. A., Ferreira, G. C., & Isaya, G. (2006) · Human Molecular Genetics

Mitochondrial Function and PathologyGenetic Neurodegenerative Diseases

Cited by 184

Friedreich Ataxia: From GAA Triplet–Repeat Expansion to Frataxin Deficiency

Patel, P. I., & Isaya, G. (2001) · The American Journal of Human Genetics

Genetic Neurodegenerative DiseasesHereditary Neurological Disorders

Cited by 126

The Ferroxidase Activity of Yeast Frataxin

Park, S., Gakh, O., Mooney, S. M., & Isaya, G. (2002) · Journal of Biological Chemistry

Metal-Catalyzed Oxygenation MechanismsMetalloenzymes and iron-sulfur proteins

Cited by 88

The Structures of Frataxin Oligomers Reveal the Mechanism for the Delivery and Detoxification of Iron

Karlberg, T., Schagerlöf, U., Gakh, O., Park, S., Ryde, U., Lindahl, M., Leath, K., Garman, E., Isaya, G., & Al-Karadaghi, S. (2006) · Structure

Enzyme Structure and FunctionNeurological diseases and metabolism

Cited by 85

Advancements in the pathophysiology of Friedreich’s Ataxia and new prospects for treatments

Babady, N. E., Carelle, N., Wells, R. D., Rouault, T. A., Hirano, M., Lynch, D. R., Delatycki, M. B., Wilson, R. B., Isaya, G., & Puccio, H. (2007) · Molecular Genetics and Metabolism

Genetic Neurodegenerative DiseasesHereditary Neurological Disorders

Cited by 73