Sadun, Alfredo A.

Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy

Yu-Wai-Man, P., Newman, N. J., Carelli, V., Moster, M. L., Biousse, V., Sadun, A. A., Klopstock, T., Vignal-Clermont, C., Sergott, R. C., Rudolph, G., et al. (2020) · Science Translational Medicine

Retinal Development and DisordersVirus-based gene therapy research

Cited by 232

International consensus statement on the clinical and therapeutic management of Leber hereditary optic neuropathy

Carelli, V., Carbonelli, M., de Coo, I. F., Kawasaki, A., Klopstock, T., Lagrèze, W. A., La Morgia, C., Newman, N. J., Orssaud, C., Pott, J. W. R., et al. (2017) · Journal of Neuro-Ophthalmology

Mitochondrial Function and PathologyCoenzyme Q10 studies and effects

Cited by 228

Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset

Newman, N. J., Yu-Wai-Man, P., Carelli, V., Moster, M. L., Biousse, V., Vignal-Clermont, C., Sergott, R. C., Klopstock, T., Sadun, A. A., Barboni, P., et al. (2021) · Ophthalmology

Retinal Development and DisordersVirus-based gene therapy research

Cited by 168

Ocular changes in TgF344-AD rat model of Alzheimer's disease

Tsai, Y., Lu, B., Ljubimov, A. V., Girman, S., Ross-Cisneros, F. N., Sadun, A. A., Svendsen, C. N., Cohen, R. M., & Wang, S. (2014) · Investigative Opthalmology & Visual Science

Alzheimer's disease research and treatmentsRetinal Diseases and Treatments

Cited by 153

Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy

Zaninello, M., Palikaras, K., Naon, D., Iwata, K., Herkenne, S., Quintana-Cabrera, R., Semenzato, M., Grespi, F., Ross-Cisneros, F. N., Carelli, V., et al. (2020) · Nature Communications

Autophagy in Disease and TherapyGlaucoma and retinal disorders

Cited by 92

Melanopsin-expressing retinal ganglion cells: implications for human diseases

La Morgia, C., Ross-Cisneros, F. N., Hannibal, J., Montagna, P., Sadun, A. A., & Carelli, V. (2011) · Vision Research

Circadian rhythm and melatoninRetinal Development and Disorders

Cited by 84

Intravitreal Gene Therapy vs. Natural History in Patients With Leber Hereditary Optic Neuropathy Carrying the m.11778G>A ND4 Mutation: Systematic Review and Indirect Comparison

Newman, N. J., Yu-Wai-Man, P., Carelli, V., Biousse, V., Moster, M. L., Vignal-Clermont, C., Sergott, R. C., Klopstock, T., Sadun, A. A., Girmens, J.-F., et al. (2021) · Frontiers in Neurology

Virus-based gene therapy researchGlaucoma and retinal disorders

Cited by 64

Receptor for advanced glycation end products is upregulated in optic neuropathy of Alzheimer's disease

Wang, M. Y., Ross-Cisneros, F. N., Aggarwal, D., Liang, C.-Y., & Sadun, A. A. (2009) · Acta Neuropathologica

Advanced Glycation End Products researchAlzheimer's disease research and treatments

Cited by 38

Safety of lenadogene nolparvovec gene therapy over 5 Years in 189 patients with leber hereditary optic neuropathy

VIGNAL-CLERMONT, C., YU-WAI-MAN, P., NEWMAN, N. J., CARELLI, V., MOSTER, M. L., BIOUSSE, V., SUBRAMANIAN, P. S., WANG, A.-G., DONAHUE, S. P., LEROY, B. P., et al. (2023) · American Journal of Ophthalmology

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 25

Cross-sectional analysis of baseline visual parameters in subjects recruited into the RESCUE and REVERSE ND4-LHON gene therapy studies

Moster, M. L., Sergott, R. C., Newman, N. J., Yu-Wai-Man, P., Carelli, V., Bryan, M. S., Smits, G., Biousse, V., Vignal-Clermont, C., Klopstock, T., et al. (2021) · Journal of Neuro-Ophthalmology

Glaucoma and retinal disordersRetinal Development and Disorders

Cited by 7