DiDonato, Joseph A.

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature

Gut microbiota and healthMetabolomics and Mass Spectrometry Studies

Cited by 5,597

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine

Gut microbiota and healthNutritional Studies and Diet

Cited by 4,386

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

Auphan, N., DiDonato, J. A., Rosette, C., Helmberg, A., & Karin, M. (1995) · Science

NF-κB Signaling PathwaysSignaling Pathways in Disease

Cited by 2,390

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., & Karin, M. (1997) · Nature

NF-κB Signaling PathwaysImmune Response and Inflammation

Cited by 2,125

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

Zhu, W., Gregory, J. C., Org, E., Buffa, J. A., Gupta, N., Wang, Z., Li, L., Fu, X., Wu, Y., Mehrabian, M., et al. (2016) · Cell

Platelet Disorders and TreatmentsGut microbiota and health

Cited by 1,968

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

Wang, Z., Roberts, A. B., Buffa, J. A., Levison, B. S., Zhu, W., Org, E., Gu, X., Huang, Y., Zamanian-Daryoush, M., Culley, M. K., et al. (2015) · Cell

Gut microbiota and healthAtherosclerosis and Cardiovascular Diseases

Cited by 1,317

A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors

Nemet, I., Saha, P. P., Gupta, N., Zhu, W., Romano, K. A., Skye, S. M., Cajka, T., Mohan, M. L., Li, L., Wu, Y., et al. (2020) · Cell

Gut microbiota and healthMetabolomics and Mass Spectrometry Studies

Cited by 784

Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†

Didonato, J., Mercurio, F., Rosette, C., Wu-Li, J., Suyang, H., Ghosh, S., & Karin, M. (1996) · Molecular and Cellular Biology

NF-κB Signaling PathwaysImmune Response and Inflammation

Cited by 707

Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential

Roberts, A. B., Gu, X., Buffa, J. A., Hurd, A. G., Wang, Z., Zhu, W., Gupta, N., Skye, S. M., Cody, D. B., Levison, B. S., et al. (2018) · Nature Medicine

Gut microbiota and healthBlood Coagulation and Thrombosis Mechanisms

Cited by 552

γ-Butyrobetaine Is a Proatherogenic Intermediate in Gut Microbial Metabolism of L-Carnitine to TMAO

Koeth, R. A., Levison, B. S., Culley, M. K., Buffa, J. A., Wang, Z., Gregory, J. C., Org, E., Wu, Y., Li, L., Smith, J. D., et al. (2014) · Cell Metabolism

Gut microbiota and healthPolyamine Metabolism and Applications

Cited by 546

Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

Gregory, J. C., Buffa, J. A., Org, E., Wang, Z., Levison, B. S., Zhu, W., Wagner, M. A., Bennett, B. J., Li, L., DiDonato, J. A., et al. (2015) · Journal of Biological Chemistry

Gut microbiota and healthAtherosclerosis and Cardiovascular Diseases

Cited by 486

Phosphorylation of IκBα Precedes but Is Not Sufficient for Its Dissociation from NF-κB

DiDonato, J. A., Mercurio, F., & Karin, M. (1995) · Molecular and Cellular Biology

NF-κB Signaling PathwaysSignaling Pathways in Disease

Cited by 337

l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans

Koeth, R. A., Lam-Galvez, B. R., Kirsop, J., Wang, Z., Levison, B. S., Gu, X., Copeland, M. F., Bartlett, D., Cody, D. B., Dai, H. J., et al. (2018) · Journal of Clinical Investigation

Gut microbiota and healthNutritional Studies and Diet

Cited by 327

Paradoxical association of enhanced cholesterol efflux with increased incident cardiovascular risks

Li, X.-M., Tang, W. H. W., Mosior, M. K., Huang, Y., Wu, Y., Matter, W., Gao, V., Schmitt, D., DiDonato, J. A., Fisher, E. A., et al. (2013) · Arteriosclerosis, Thrombosis, and Vascular Biology

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 301

Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex

Huang, Y., Wu, Z., Riwanto, M., Gao, S., Levison, B. S., Gu, X., Fu, X., Wagner, M. A., Besler, C., Gerstenecker, G., et al. (2013) · Journal of Clinical Investigation

Paraoxonase enzyme and polymorphismsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 269

Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential

Skye, S. M., Zhu, W., Romano, K. A., Guo, C.-J., Wang, Z., Jia, X., Kirsop, J., Haag, B., Lang, J. M., DiDonato, J. A., et al. (2018) · Circulation Research

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 189

Gut microbiota metabolites, amino acid metabolites and improvements in insulin sensitivity and glucose metabolism: the POUNDS Lost trial

Heianza, Y., Sun, D., Li, X., DiDonato, J. A., Bray, G. A., Sacks, F. M., & Qi, L. (2019) · Gut

Gut microbiota and healthNutritional Studies and Diet

Cited by 177

Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N‐oxide‐generating pathway, modulates platelet responsiveness and thrombosis risk

Zhu, W., Buffa, J. A., Wang, Z., Warrier, M., Schugar, R., Shih, D. M., Gupta, N., Gregory, J. C., Org, E., Fu, X., et al. (2018) · Journal of Thrombosis and Haemostasis

Blood Coagulation and Thrombosis MechanismsPlatelet Disorders and Treatments

Cited by 161

Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer

Zamanian-Daryoush, M., Lindner, D. J., DiDonato, J. A., Wagner, M., Buffa, J., Rayman, P., Parks, J. S., Westerterp, M., Tall, A. R., & Hazen, S. L. (2017) · Oncotarget

Cancer, Lipids, and MetabolismCholesterol and Lipid Metabolism

Cited by 32