Jacobs, Howard T.

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 2,734

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

Mills, E. L., Kelly, B., Logan, A., Costa, A. S. H., Varma, M., Bryant, C. E., Tourlomousis, P., Däbritz, J. H. M., Gottlieb, E., Latorre, I., et al. (2016) · Cell

Immune cells in cancerMitochondrial Function and Pathology

Cited by 2,291

Human mitochondrial DNA deletions associated with mutations in the gene encoding twinkle, a phage T7 gene 4-like protein localized in mitochondria

Spelbrink, J. N., Li, F.-Y., Tiranti, V., Nikali, K., Yuan, Q.-P., Tariq, M., Wanrooij, S., Garrido, N., Comi, G., Morandi, L., et al. (2001) · Nature Genetics

Mitochondrial Function and PathologyDNA Repair Mechanisms

Cited by 882

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

Trifunovic, A., Hansson, A., Wredenberg, A., Rovio, A. T., Dufour, E., Khvorostov, I., Spelbrink, J. N., Wibom, R., Jacobs, H. T., & Larsson, N.-G. (2005) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 555

In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells

Spelbrink, J. N., Toivonen, J. M., Hakkaart, G. A. J., Kurkela, J. M., Cooper, H. M., Lehtinen, S. K., Lecrenier, N., Back, J. W., Speijer, D., Foury, F., et al. (2000) · Journal of Biological Chemistry

Mitochondrial Function and PathologyDNA Repair Mechanisms

Cited by 193

Stabilization of Hypoxia-inducible Factor-1α Protein in Hypoxia Occurs Independently of Mitochondrial Reactive Oxygen Species Production

Chua, Y. L., Dufour, E., Dassa, E. P., Rustin, P., Jacobs, H. T., Taylor, C. T., & Hagen, T. (2010) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 189

Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks

Pohjoismäki, J. L. O., Goffart, S., Tyynismaa, H., Willcox, S., Ide, T., Kang, D., Suomalainen, A., Karhunen, P. J., Griffith, J. D., Holt, I. J., et al. (2009) · Journal of Biological Chemistry

Mitochondrial Function and PathologyDNA Repair Mechanisms

Cited by 122

Engineering the alternative oxidase gene to better understand and counteract mitochondrial defects: state of the art and perspectives

El‐Khoury, R., Kemppainen, K. K., Dufour, E., Szibor, M., Jacobs, H. T., & Rustin, P. (2014) · British Journal of Pharmacology

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 56

Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy number

Pohjoismäki, J. L. O., Goffart, S., Taylor, R. W., Turnbull, D. M., Suomalainen, A., Jacobs, H. T., & Karhunen, P. J. (2010) · PLoS ONE

Mitochondrial Function and PathologyGenomic variations and chromosomal abnormalities

Cited by 50

What physiological role(s) does the alternative oxidase perform in animals?

Jacobs, H. T., & Ballard, J. W. O. (2022) · Biochimica et Biophysica Acta (BBA) - Bioenergetics

Mitochondrial Function and PathologyPhysiological and biochemical adaptations

Cited by 25