Tosh, Justin

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP

Wiseman, F. K., Pulford, L. J., Barkus, C., Liao, F., Portelius, E., Webb, R., Chávez-Gutiérrez, L., Cleverley, K., Noy, S., Sheppard, O., et al. (2018) · Brain

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 133

Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of down syndrome-related phenotypes.

Lana-Elola, E., Cater, H., Watson-Scales, S., Greenaway, S., Müller-Winkler, J., Gibbins, D., Nemes, M., Slender, A., Hough, T., Keskivali-Bond, P., et al. (2021) · Disease Models & Mechanisms

Down syndrome and intellectual disability researchWilliams Syndrome Research

Cited by 35

Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models

Tosh, J. L., Rhymes, E. R., Mumford, P., Whittaker, H. T., Pulford, L. J., Noy, S. J., Cleverley, K., LonDownS Consortium, Strydom, A., Fisher, E., et al. (2021) · Scientific Reports

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 26

Mouse models of aneuploidy to understand chromosome disorders

Tosh, J., Tybulewicz, V., & Fisher, E. M. C. (2022) · Mammalian Genome

Down syndrome and intellectual disability researchGenomic variations and chromosomal abnormalities

Cited by 24

Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21

Mumford, P., Tosh, J., Anderle, S., Gkanatsiou Wikberg, E., Lau, G., Noy, S., Cleverley, K., Saito, T., Saido, T. C., Yu, E., et al. (2022) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 22