Shostak, Alena

Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

Kim, H., Leng, K., Park, J., Sorets, A. G., Kim, S., Shostak, A., Embalabala, R. J., Mlouk, K., Katdare, K. A., Rose, I. V. L., et al. (2022) · Nature Communications

Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 201

Stress-impaired transcription factor expression and insulin secretion in transplanted human islets

Dai, C., Kayton, N. S., Shostak, A., Poffenberger, G., Cyphert, H. A., Aramandla, R., Thompson, C., Papagiannis, I. G., Emfinger, C., Shiota, M., et al. (2016) · Journal of Clinical Investigation

Pancreatic function and diabetesEndoplasmic Reticulum Stress and Disease

Cited by 109

PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer’s disease

Nackenoff, A. G., Hohman, T. J., Neuner, S. M., Akers, C. S., Weitzel, N. C., Shostak, A., Ferguson, S. M., Mobley, B., Bennett, D. A., Schneider, J. A., et al. (2021) · PLOS Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 59

Elucidating brain transport pathways and cell type-dependent gene silencing of a durable lipid–siRNA conjugate administered into cerebrospinal fluid

Sorets, A. G., Schwensen, K. R., Francini, N., Kjar, A., Abdulrahman, A. M., Shostak, A., Katdare, K. A., Schoch, K. M., Cowell, R. P., Park, J. C., et al. (2025) · Nucleic Acids Research

RNA Interference and Gene DeliveryBarrier Structure and Function Studies

Cited by 6

Lipid-siRNA conjugate accesses a perivascular transport mechanism and achieves widespread and durable knockdown in the central nervous system

Sorets, A., Schwensen, K., Francini, N., Kjar, A., Abdulrahman, A., Shostak, A., Katdare, K., Schoch, K., Cowell, R., Park, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory)

RNA Interference and Gene DeliveryBarrier Structure and Function Studies

Cited by 4