Bruick, Richard K.

A conserved family of prolyl-4-hydroxylases that modify HIF

Bruick, R. K., & McKnight, S. L. (2001) · Science

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 2,549

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., & Bruick, R. K. (2002) · Genes & Development

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 1,550

Targeting renal cell carcinoma with a HIF-2 antagonist

Chen, W., Hill, H., Christie, A., Kim, M. S., Holloman, E., Pavia-Jimenez, A., Homayoun, F., Ma, Y., Patel, N., Yell, P., et al. (2016) · Nature

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 709

A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver

Yamashita, H., Takenoshita, M., Sakurai, M., Bruick, R. K., Henzel, W. J., Shillinglaw, W., Arnot, D., & Uyeda, K. (2001) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerDiet, Metabolism, and Disease

Cited by 682

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

Cho, H., Du, X., Rizzi, J. P., Liberzon, E., Chakraborty, A. A., Gao, W., Carvo, I., Signoretti, S., Bruick, R. K., Josey, J. A., et al. (2016) · Nature

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 451

An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis

Salahudeen, A. A., Thompson, J. W., Ruiz, J. C., Ma, H.-W., Kinch, L. N., Li, Q., Grishin, N. V., & Bruick, R. K. (2009) · Science

Iron Metabolism and DisordersUbiquitin and proteasome pathways

Cited by 432

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

Scheuermann, T. H., Li, Q., Ma, H.-W., Key, J., Zhang, L., Chen, R., Garcia, J. A., Naidoo, J., Longgood, J., Frantz, D. E., et al. (2013) · Nature Chemical Biology

Cancer, Hypoxia, and MetabolismHeterocyclic Compound Synthesis and Bioactivity

Cited by 315

Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor

Scheuermann, T. H., Tomchick, D. R., Machius, M., Guo, Y., Bruick, R. K., & Gardner, K. H. (2009) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismHemoglobin structure and function

Cited by 301

Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?

Ozer, A., & Bruick, R. K. (2007) · Nature Chemical Biology

Metal-Catalyzed Oxygenation MechanismsCancer-related gene regulation

Cited by 214

Activation of the HIF Prolyl Hydroxylase by the Iron Chaperones PCBP1 and PCBP2

Nandal, A., Ruiz, J. C., Subramanian, P., Ghimire-Rijal, S., Sinnamon, R. A., Stemmler, T. L., Bruick, R. K., & Philpott, C. C. (2011) · Cell Metabolism

Iron Metabolism and DisordersCancer, Hypoxia, and Metabolism

Cited by 204

Structure of factor-inhibiting hypoxia-inducible factor 1: an asparaginyl hydroxylase involved in the hypoxic response pathway

Dann, C. E., Bruick, R. K., & Deisenhofer, J. (2002) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 200

Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5)

Thompson, J. W., Salahudeen, A. A., Chollangi, S., Ruiz, J. C., Brautigam, C. A., Makris, T. M., Lipscomb, J. D., Tomchick, D. R., & Bruick, R. K. (2012) · Journal of Biological Chemistry

Iron Metabolism and DisordersHemoglobin structure and function

Cited by 71

Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control

Cheng, X., Prange-Barczynska, M., Fielding, J. W., Zhang, M., Burrell, A. L., Lima, J. D. C. C., Eckardt, L., Argles, I. L. A., Pugh, C. W., Buckler, K. J., et al. (2020) · Journal of Clinical Investigation

Neuroscience of respiration and sleepCancer, Hypoxia, and Metabolism

Cited by 62

Effect of acute and chronic xenon inhalation on erythropoietin, hematological parameters, and athletic performance

Dias, K. A., Lawley, J. S., Gatterer, H., Howden, E. J., Sarma, S., Cornwell, W. K., Hearon, C. M., Samels, M., Everding, B., Liang, A. S.-W., et al. (2019) · Journal of Applied Physiology

Erythropoietin and Anemia TreatmentHigh Altitude and Hypoxia

Cited by 16