Kirschke, Elaine

Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles

Kirschke, E., Goswami, D., Southworth, D., Griffin, P. R., & Agard, D. A. (2014) · Cell

Heat shock proteins researchProtein Structure and Dynamics

Cited by 399

Structure of Hsp90–Hsp70–Hop–GR reveals the Hsp90 client-loading mechanism

Wang, R. Y.-R., Noddings, C. M., Kirschke, E., Myasnikov, A. G., Johnson, J. L., & Agard, D. A. (2022) · Nature

Heat shock proteins researchProtein Structure and Dynamics

Cited by 220

Hsp70 Forms Antiparallel Dimers Stabilized by Post-translational Modifications to Position Clients for Transfer to Hsp90

Morgner, N., Schmidt, C., Beilsten-Edmands, V., Ebong, I.-O., Patel, N. A., Clerico, E. M., Kirschke, E., Daturpalli, S., Jackson, S. E., Agard, D., et al. (2015) · Cell Reports

Heat shock proteins researchUbiquitin and proteasome pathways

Cited by 106

GR chaperone cycle mechanism revealed by cryo-EM: inactivation of GR by GR:Hsp90:Hsp70:Hop client-loading complex

Wang, R. Y.-R., Noddings, C. M., Kirschke, E., Myasnikov, A. G., Johnson, J. L., & Agard, D. A. (2020) · bioRxiv (Cold Spring Harbor Laboratory)

Heat shock proteins researchProtein Structure and Dynamics

Cited by 10

The interplay between Bag-1, Hsp70, and Hsp90 reveals that inhibiting Hsp70 rebinding is essential for Glucocorticoid Receptor activity

Kirschke, E., Roe-Zurz, Z., Noddings, C., & Agard, D. (2020) · bioRxiv (Cold Spring Harbor Laboratory)

Heat shock proteins researchReceptor Mechanisms and Signaling

Cited by 6