Kane, Lesley A.

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

Lazarou, M., Sliter, D. A., Kane, L. A., Sarraf, S. A., Wang, C., Burman, J. L., Sideris, D. P., Fogel, A. I., & Youle, R. J. (2015) · Nature

Autophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

Cited by 2,774

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

Jin, S. M., Lazarou, M., Wang, C., Kane, L. A., Narendra, D. P., & Youle, R. J. (2010) · Journal of Cell Biology

Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and Pathology

Cited by 1,375

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

Kane, L. A., Lazarou, M., Fogel, A. I., Li, Y., Yamano, K., Sarraf, S. A., Banerjee, S., & Youle, R. J. (2014) · Journal of Cell Biology

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

Cited by 1,298

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

Lazarou, M., Jin, S. M., Kane, L. A., & Youle, R. J. (2012) · Developmental Cell

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 670

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

Hasson, S. A., Kane, L. A., Yamano, K., Huang, C.-H., Sliter, D. A., Buehler, E., Wang, C., Heman-Ackah, S. M., Hessa, T., Guha, R., et al. (2013) · Nature

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 365

Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier

Barker, S. J., Thayer, M. B., Kim, C., Tatarakis, D., Simon, M. J., Dial, R., Nilewski, L., Wells, R. C., Zhou, Y., Afetian, M., et al. (2024) · Science Translational Medicine

RNA Interference and Gene DeliveryBarrier Structure and Function Studies

Cited by 142

Modulation of mitochondrial proteome and improved mitochondrial function by biventricular pacing of dyssynchronous failing hearts

Agnetti, G., Kaludercic, N., Kane, L. A., Elliott, S. T., Guo, Y., Chakir, K., Samantapudi, D., Paolocci, N., Tomaselli, G. F., Kass, D. A., et al. (2010) · Circulation Cardiovascular Genetics

Cardiac pacing and defibrillation studiesMitochondrial Function and Pathology

Cited by 117

Decreased lipidated ApoE‐receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes

Guo, J. L., Braun, D., Fitzgerald, G. A., Hsieh, Y.-T., Rougé, L., Litvinchuk, A., Steffek, M., Propson, N. E., Heffner, C. M., Discenza, C., et al. (2025) · Cell

Alzheimer's disease research and treatmentsLysosomal Storage Disorders Research

Cited by 91

Site-Mapping of In Vitro S-nitrosation in Cardiac Mitochondria: Implications for Cardioprotection

Murray, C. I., Kane, L. A., Uhrigshardt, H., Wang, S.-B., & Van Eyk, J. E. (2011) · Molecular & Cellular Proteomics

Redox biology and oxidative stressCardiac Ischemia and Reperfusion

Cited by 63