Ornelas, Elizabeth

Harnessing the anti-cancer natural product nimbolide for targeted protein degradation

Spradlin, J. N., Hu, X., Ward, C. C., Brittain, S. M., Jones, M. D., Ou, L., To, M., Proudfoot, A., Ornelas, E., Woldegiorgis, M., et al. (2019) · Nature Chemical Biology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 432

Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy

Bonazzi, S., d’Hennezel, E., Beckwith, R. E. J., Xu, L., Fazal, A., Magracheva, A., Ramesh, R., Cernijenko, A., Antonakos, B., Bhang, H.-E. C., et al. (2023) · Cell Chemical Biology

Protein Degradation and InhibitorsCancer Immunotherapy and Biomarkers

Cited by 167

A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction

Ting, P. Y., Borikar, S., Kerrigan, J. R., Thomsen, N. M., Aghania, E., Hinman, A. E., Reyes, A., Pizzato, N., Fodor, B. D., Wu, F., et al. (2024) · Science

Hemoglobinopathies and Related DisordersProtein Degradation and Inhibitors

Cited by 97

Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon

Ma, X., Leon, B., Ornelas, E., Dovala, D., Tandeske, L., Luu, C., Pardee, G., Widger, S., Solomon, J. M., Beckwith, R. E. J., et al. (2023) · Scientific Reports

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 21

Discovery and Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease

Kerrigan, J. R., Thomsen, N. M., Cernijenko, A., Kochanek, S. E., Dewhurst, J., O’Brien, G., Ware, N. F., Sanchez, C. C., Manning, J. R., Ma, X., et al. (2024) · Journal of Medicinal Chemistry

Hemoglobinopathies and Related DisordersProtein Degradation and Inhibitors

Cited by 15