Chandra, Tamir

cGAS surveillance of micronuclei links genome instability to innate immunity

Mackenzie, K. J., Carroll, P., Martin, C.-A., Murina, O., Fluteau, A., Simpson, D. J., Olova, N., Sutcliffe, H., Rainger, J. K., Leitch, A., et al. (2017) · Nature

interferon and immune responsesImmune Response and Inflammation

Cited by 1,752

SC3: consensus clustering of single-cell RNA-seq data

Kiselev, V. Y., Kirschner, K., Schaub, M. T., Andrews, T., Yiu, A., Chandra, T., Natarajan, K. N., Reik, W., Barahona, M., Green, A. R., et al. (2017) · Nature Methods

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 1,500

Guidelines for minimal information on cellular senescence experimentation in vivo

Ogrodnik, M., Carlos Acosta, J., Adams, P. D., d’Adda di Fagagna, F., Baker, D. J., Bishop, C. L., Chandra, T., Collado, M., Gil, J., Gorgoulis, V., et al. (2024) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 376

Global reorganization of the nuclear landscape in senescent cells

Chandra, T., Ewels, P. A., Schoenfelder, S., Furlan-Magaril, M., Wingett, S. W., Kirschner, K., Thuret, J.-Y., Andrews, S., Fraser, P., & Reik, W. (2015) · Cell Reports

Genomics and Chromatin DynamicsNuclear Structure and Function

Cited by 348

Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence.

Sadaie, M., Salama, R., Carroll, T., Tomimatsu, K., Chandra, T., Young, A. R. J., Narita, M., Pérez-Mancera, P. A., Bennett, D. C., Chong, H., et al. (2013) · Genes & Development

Nuclear Structure and FunctionTelomeres, Telomerase, and Senescence

Cited by 323

Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation

Chandra, T., Kirschner, K., Thuret, J.-Y., Pope, B. D., Ryba, T., Newman, S., Ahmed, K., Samarajiwa, S. A., Salama, R., Carroll, T., et al. (2012) · Molecular Cell

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 308

Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer

Haston, S., Gonzalez-Gualda, E., Morsli, S., Ge, J., Reen, V., Calderwood, A., Moutsopoulos, I., Panousopoulos, L., Deletic, P., Carreno, G., et al. (2023) · Cancer Cell

Telomeres, Telomerase, and SenescenceImmune cells in cancer

Cited by 251

An epigenome-wide association study of sex-specific chronological ageing

McCartney, D. L., Zhang, F., Hillary, R. F., Zhang, Q., Stevenson, A. J., Walker, R. M., Bermingham, M. L., Boutin, T., Morris, S. W., Campbell, A., et al. (2020) · Genome Medicine

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 152

Notch Signaling Mediates Secondary Senescence

Teo, Y. V., Rattanavirotkul, N., Olova, N., Salzano, A., Quintanilla, A., Tarrats, N., Kiourtis, C., Müller, M., Green, A. R., Adams, P. D., et al. (2019) · Cell Reports

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 149

Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects

Robertson, N. A., Latorre-Crespo, E., Terradas-Terradas, M., Lemos-Portela, J., Purcell, A. C., Livesey, B. J., Hillary, R. F., Murphy, L., Fawkes, A., MacGillivray, L., et al. (2022) · Nature Medicine

Acute Myeloid Leukemia ResearchCancer Genomics and Diagnostics

Cited by 132

Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence

Aarts, M., Georgilis, A., Beniazza, M., Beolchi, P., Banito, A., Carroll, T., Kulisic, M., Kaemena, D. F., Dharmalingam, G., Martin, N., et al. (2017) · Genes & Development

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 64

Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

O’Sullivan, E. D., Mylonas, K. J., Bell, R., Carvalho, C., Baird, D. P., Cairns, C., Gallagher, K. M., Campbell, R., Docherty, M., Laird, A., et al. (2022) · JCI Insight

Telomeres, Telomerase, and SenescenceAcute Kidney Injury Research

Cited by 43

Promises of reprogramming-induced rejuvenation

Simpson, D. J., Arif, N., Suwanlikit, Y., Kirschner, K., & Chandra, T. (2026) · Current Opinion in Genetics & Development

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 2