Mathieu, Patrick

RNA expression profile of calcified bicuspid, tricuspid, and normal human aortic valves by RNA sequencing

Guauque-Olarte, S., Droit, A., Tremblay-Marchand, J., Gaudreault, N., Kalavrouziotis, D., Dagenais, F., Seidman, J. G., Body, S. C., Pibarot, P., Mathieu, P., et al. (2016) · Physiological Genomics

Cardiac Valve Diseases and TreatmentsAortic Disease and Treatment Approaches

Cited by 82

Lipoprotein(a) and Calcific Aortic Valve Stenosis Progression: A Systematic Review and Meta-Analysis

Arsenault, B. J., Loganath, K., Girard, A., Botezatu, S., Zheng, K. H., Tzolos, E., Abdoun, K., Tastet, L., Capoulade, R., Côté, N., et al. (2024) · JAMA Cardiology

Cardiac Valve Diseases and TreatmentsAortic Disease and Treatment Approaches

Cited by 80

The pathology and pathobiology of bicuspid aortic valve: State of the art and novel research perspectives

Mathieu, P., Bossé, Y., Huggins, G. S., Corte, A. D., Pibarot, P., Michelena, H. I., Limongelli, G., Boulanger, M., Evangelista, A., Bédard, E., et al. (2015) · The Journal of Pathology: Clinical Research

Aortic Disease and Treatment ApproachesCardiac Valve Diseases and Treatments

Cited by 76

Calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve Disease

Guauque-Olarte, S., Messika-Zeitoun, D., Droit, A., Lamontagne, M., Tremblay-Marchand, J., Lavoie-Charland, E., Gaudreault, N., Arsenault, B. J., Dubé, M.-P., Tardif, J.-C., et al. (2015) · Circulation: Cardiovascular Genetics

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 72

Increased Biglycan in Aortic Valve Stenosis Leads to the Overexpression of Phospholipid Transfer Protein via Toll-Like Receptor 2

Derbali, H., Bossé, Y., Côté, N., Pibarot, P., Audet, A., Pépin, A., Arsenault, B., Couture, C., Després, J.-P., & Mathieu, P. (2010) · The American Journal of Pathology

Cardiac Valve Diseases and TreatmentsProteoglycans and glycosaminoglycans research

Cited by 71

Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis

Chen, H. Y., Cairns, B. J., Small, A. M., Burr, H. A., Ambikkumar, A., Martinsson, A., Thériault, S., Munter, H. M., Steffen, B., Zhang, R., et al. (2020) · JAMA Cardiology

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 65

Impact of Plasma Lp-PLA2 Activity on the Progression of Aortic Stenosis

Capoulade, R., Mahmut, A., Tastet, L., Arsenault, M., Bédard, É., Dumesnil, J. G., Després, J.-P., Larose, É., Arsenault, B. J., Bossé, Y., et al. (2015) · JACC: Cardiovascular Imaging

Cardiac Valve Diseases and TreatmentsLipoproteins and Cardiovascular Health

Cited by 61

Age-related differences in the pathogenesis of calcific aortic stenosis: The potential role of resistin

Mohty, D., Pibarot, P., Després, J.-P., Cartier, A., Arsenault, B., Picard, F., & Mathieu, P. (2010) · International Journal of Cardiology

Cardiac Valve Diseases and TreatmentsAdipokines, Inflammation, and Metabolic Diseases

Cited by 53

Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation

Thériault, S., Li, Z., Abner, E., Luan, J., Manikpurage, H. D., Houessou, U., Zamani, P., Briend, M., Estonian Biobank Research Team, Boudreau, D. K., et al. (2024) · Nature Communications

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 49

Adenosine derived from ecto-nucleotidases in calcific aortic valve disease promotes mineralization through A2a adenosine receptor

Mahmut, A., Boulanger, M.-C., Bouchareb, R., Hadji, F., & Mathieu, P. (2015) · Cardiovascular Research

Adenosine and Purinergic SignalingCardiac Valve Diseases and Treatments

Cited by 48

B-Type Natriuretic Peptide and High-Sensitivity Cardiac Troponin for Risk Stratification in Low-Flow, Low-Gradient Aortic Stenosis

Dahou, A., Clavel, M.-A., Capoulade, R., O’Connor, K., Ribeiro, H. B., Côté, N., Le Ven, F., Rodés-Cabau, J., Dumesnil, J. G., Mathieu, P., et al. (2018) · JACC: Cardiovascular Imaging

Cardiac Valve Diseases and TreatmentsAortic Disease and Treatment Approaches

Cited by 37

Lipoprotein lipase in aortic valve stenosis is associated with lipid retention and remodelling

Mahmut, A., Boulanger, M., Fournier, D., Couture, C., Trahan, S., Pagé, S., Arsenault, B., Després, J., Pibarot, P., & Mathieu, P. (2013) · European Journal of Clinical Investigation

Cardiac Valve Diseases and TreatmentsAtherosclerosis and Cardiovascular Diseases

Cited by 31

Carbonic anhydrase XII in valve interstitial cells promotes the regression of calcific aortic valve stenosis

Bouchareb, R., Côté, N., Marie-Chloé-Boulanger, Le Quang, K., El Husseini, D., Asselin, J., Hadji, F., Lachance, D., Shayhidin, E. E., Mahmut, A., et al. (2015) · Journal of Molecular and Cellular Cardiology

Cardiac Valve Diseases and TreatmentsEnzyme function and inhibition

Cited by 25

Phenome-wide analyses establish a specific association between aortic valve PALMD expression and calcific aortic valve stenosis

Li, Z., Gaudreault, N., Arsenault, B. J., Mathieu, P., Bossé, Y., & Thériault, S. (2020) · Communications Biology

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 23

Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction

Small, A. M., Yang, T.-Y., Itoh, S., Thériault, S., Dufresne, L., Kurosawa, R., Komuro, I., Matsuda, K., Vy, H. M. T., Farber-Eger, E. H., et al. (2026) · Nature Genetics

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 18

Enhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesis

Chignon, A., Rosa, M., Boulanger, M.-C., Argaud, D., Devillers, R., Bon-Baret, V., Mkannez, G., Li, Z., Rufiange, A., Gaudreault, N., et al. (2021) · iScience

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 18

Transcriptomic signatures of calcific aortic valve stenosis severity in human tricuspid and bicuspid aortic valves

Houessou, U., Zamani, P., Manikpurage, H. D., Li, Z., Gaudreault, N., Dahmene, M., Dagenais, F., Couture, C., Clavel, M.-A., Pibarot, P., et al. (2025) · JACC: Basic to Translational Science

Cardiac Valve Diseases and TreatmentsAortic Disease and Treatment Approaches

Cited by 11

A transcriptomic approach to sex differences in calcific aortic valve stenosis in patients with a tricuspid aortic valve

Le Nezet, E., Tam, R., Li, Z., Gaudreault, N., Mathieu, P., Côté, N., Guisle, I., Thériault, S., Bossé, Y., & Clavel, M.-A. (2025) · CJC Open

Cardiac Valve Diseases and TreatmentsAortic Disease and Treatment Approaches

Cited by 5

Aortic valve-specific genes dysregulated in calcific aortic valve stenosis as potential biomarkers and therapeutic targets

Zamani, P., Houessou, U., Manikpurage, H. D., Li, Z., Dahmene, M., Gaudreault, N., Dagenais, F., Clavel, M.-A., Pibarot, P., Arsenault, B. J., et al. (2025) · Human Genetics and Genomics Advances

Cardiac Valve Diseases and TreatmentsAortic Disease and Treatment Approaches

Cited by 3

Sex-specific gene expression signatures of calcific aortic valve stenosis in a large collection of human tissues

Houessou, U., Zamani, P., Manikpurage, H. D., Li, Z., Gaudreault, N., Dahmene, M., Dagenais, F., Couture, C., Clavel, M.-A., Pibarot, P., et al. (2026) · Atherosclerosis

Cardiac Valve Diseases and TreatmentsGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Cited by 1

Connecting proteomics and genomics to identify causal biomarkers specific for aortic valve stenosis

Zamani, P., Houessou, U., Manikpurage, H. D., Dahmene, M., Li, Z., Gaudreault, N., Clavel, M.-A., Pibarot, P., Mathieu, P., Arsenault, B. J., et al. (2025) · medRxiv

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 0